Publications by authors named "Sogol Stephanie Javadi"

Article Synopsis
  • Palmoplantar pustulosis is a chronic skin condition related to psoriasis, characterized by itchy pustules on the palms and soles.
  • The disorder has a variety of genetic and environmental causes, is relatively rare, and can be difficult to treat, often causing significant discomfort for those affected.
  • This systemic review analyzes newer treatment options published between 2015 and 2022, highlighting current therapies such as topical agents, oral medications, and phototherapy.
View Article and Find Full Text PDF

Introduction: Psoriatic arthritis is estimated to develop in 2% of patients with psoriasis per year and can result in significant morbidity. Early diagnosis and treatment of psoriatic arthritis are imperative to prevent irreversible arthritic joint damage. Dermatologists play a key role in identifying patients who are at risk for or with early signs of psoriatic arthritis.

View Article and Find Full Text PDF
Article Synopsis
  • Biologics can trigger the production of anti-drug antibodies (ADAs) in patients, but their clinical significance remains unclear, especially in those with psoriasis treated with IL-17 inhibitors.
  • A systematic review of 17 studies revealed varying ADA incidence rates for different drugs, with brodalumab showing a notable decrease in efficacy among ADA-positive patients.
  • Monitoring ADAs and titers may not be necessary for secukinumab and bimekizumab, but it could be beneficial for brodalumab and ixekizumab in clinical settings.
View Article and Find Full Text PDF

Introduction: Little is known about the effects of HIV reservoir research at the end of life on staff members involved. Staff members' perceptions and experiences were assessed related to their involvement in the Last Gift, a rapid autopsy study at the University of California San Diego enrolling people living with HIV who are terminally ill and have a desire to contribute to HIV cure-related research.

Methods: Two focus group discussions consisting of clinical (n = 7) and rapid research autopsy (n = 8) staff members were conducted to understand the perspectives of staff members and the impact the Last Gift rapid autopsy study had on them.

View Article and Find Full Text PDF

End-of-life (EOL) HIV cure-related research provides a novel approach to studying HIV reservoirs. The Last Gift is a rapid autopsy research study at the University of California San Diego that enrolls terminally ill people living with HIV (PLWHIV) with a desire to contribute to HIV cure-related research. We conducted in-depth baseline and follow-up interviews with Last Gift study participants.

View Article and Find Full Text PDF

A growing number of people living with HIV/AIDS are participating in HIV cure-related research at the end of life (EOL). Due to the novelty of EOL HIV cure-related research, there is a need to understand how their next-of-kin (NOK) perceive such research. We conducted in-depth interviews with NOK of the Last Gift study participants at the University of California, San Diego.

View Article and Find Full Text PDF