Publications by authors named "Sofija Semeniuk"
Immune cells play a pivotal role in the establishment, growth, and progression of tumors at primary and metastatic sites. Macrophages, in particular, play a critical role in suppressing immune responses and promoting an anti-inflammatory environment through both direct and indirect cell-cell interactions. However, our understanding of the mechanisms underlying such interactions is limited due to a lack of reliable tools for studying transient interactions between cancer cells and macrophages within the tumor microenvironment.
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- CHO cells are essential in the biopharmaceutical industry, prompting extensive use of genetic engineering techniques like CRISPR-Cas to enhance their performance in protein production.
- This review highlights recent advances using various CRISPR-Cas systems to improve recombinant protein output in CHO cells while discussing the benefits, limitations, and challenges of these methods.
- Emphasis is placed on how gene regulation affects glycan composition, influencing the properties of therapeutic proteins, and the future potential of CRISPR technology for developing more efficient CHO cell lines, necessitating further research to unlock its full capabilities.