BCNNM: A Framework for Neural Tissue Development Modeling.

Cerebral ("brain") organoids are high-fidelity cellular models of the developing brain, which makes them one of the go-to methods to study isolated processes of tissue organization and its electrophysiological properties, allowing to collect invaluable data for modeling neurodevelopmental processes. Complex computer models of biological systems supplement and experimentation and allow researchers to look at things that no laboratory study has access to, due to either technological or ethical limitations. In this paper, we present the Biological Cellular Neural Network Modeling (BCNNM) framework designed for building dynamic spatial models of neural tissue organization and basic stimulus dynamics.