Publications by authors named "Sofie Hagelund"
Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well documented. In addition, TRAIL has been shown to preferentially kill tumor cells, raising hope for the development of targeted anti-cancer therapies.
View Article and Find Full Text PDFTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an important mediator of tumor immune surveillance. In addition, its potential to kill cancer cells without harming healthy cells led to the development of TRAIL receptor agonists, which however did not show the desired effects in clinical trials. This is caused mainly by apoptosis resistance mechanisms operating in primary cancer cells.
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- Increased metabolic acid production in many cancers disrupts pH balance, with V-ATPases playing a role in acid extrusion and cancer invasiveness.
- Research focused on the a3 subunit of V-ATPase in pancreatic ductal adenocarcinoma (PDAC) revealed higher levels in cancer cells compared to normal cells.
- Knockdown of a3 did not affect pH regulation or cell growth but surprisingly increased migration and invasion in PDAC cells, indicating it negatively regulates these processes possibly through its impact on extracellular matrix degradation.