Publications by authors named "Sofie C A Ten Brink"
Complement factor H (CFH) common genetic variants have been associated with age-related macular degeneration (AMD). While most previous in vitro RPE studies focused on the common p.His402Tyr CFH variant, we characterized rare CFH variants that are highly penetrant for AMD using induced pluripotent stem-cell-derived retinal pigment epithelium (iPSC-RPE).
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- Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, particularly in Western countries.
- AMD has multiple contributing factors, especially a significant genetic element to its development.
- Researchers created induced pluripotent stem cells (iPSCs) from blood cells of three individuals over 70 without AMD to use as control lines for studying disease mechanisms and exploring treatment options for AMD.
Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. AMD is multifactorial eye disease with a strong genetic contribution. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells of three patients with AMD carrying rare variants in the complement factor H (CFH) gene.
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- RSV poses a significant health risk to older adults, yet there is limited research on how their immune systems respond to the virus, which complicates vaccine and treatment development.
- In a study involving older adults (≥60 years) over three winters, researchers tracked immune responses by analyzing serum and nasal swabs for antibodies and cytokines during RSV infection and recovery.
- The results showed increased antibody responses and local cytokine production in infected individuals, highlighting important immune mechanisms that could inform future RSV prevention and therapy strategies in older populations.