Publications by authors named "Sofiane Mokrani"
Article Synopsis
- - XLF/Cernunnos is part of a key DNA repair system called classical non-homologous end-joining (cNHEJ), which helps fix DNA double-strand breaks.
- - Research on Xlf-/- mice shows they experience neurodevelopmental delays, behavioral changes, and microcephaly, similar to humans with cNHEJ deficiencies; this is linked to increased neural cell apoptosis and premature neurogenesis.
- - The study finds that XLF is crucial for normal brain development by maintaining balanced divisions of neural progenitors, and disruption of this can lead to developmental issues and stress-related pathologies.
High fidelity of genetic transmission in neural stem and progenitor cells (NSPCs) has been long time considered to be crucial for brain development and homeostasis. However, recent studies have identified recurrent DSB clusters in dividing NSPCs, which may underlie the diversity of neuronal cell types. This raised the interest in understanding how NSPCs sense and repair DSBs and how this mechanism could be altered by environmental genotoxic stress caused by pollutants or ionizing radiation.
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