Publications by authors named "Sofia Valle"
Article Synopsis
- Metabolic syndrome (MS) negatively impacts reproductive health in female mice, leading to issues like disrupted estrous cycles and impaired reproductive success.
- In the study, mice on a high-fat diet showed signs of MS, such as insulin resistance and hormonal imbalances, which affected their endometrial health and reproductive outcomes.
- Treatment with metformin improved these reproductive issues by normalizing hormone levels and restoring proper endometrial function, suggesting potential benefits for women with MS seeking to enhance reproductive health.
Visceral Leishmaniasis is one of the most important vector-borne zoonoses in the world. In 2013, the first autochthonous canine case of the disease in the state of Paraná, southern region of Brazil, was reported in Foz do Iguaçu, on the triple border between Brazil, Argentina and Paraguay. In 2015, the first human case was related.
View Article and Find Full Text PDFIn spite of the low frequency of COVID-19 associated bacterial coinfections, the rate of empiric antibiotic use varies between 70% and 90%. The primary objective of this study was to evaluate the impact of an antimicrobial stewardship program (ASP) on COVID-19 patients. The study design was an interrupted time series, assessing prevalence of antibiotic use, adequacy of treatment and antimicrobial consumption in adult patients hospitalized with COVID before the COVID-ASP implementation in June 2020, and on three subsequent periods (P2 in August 2020, P3 in October 2020 and P4 in June 2021).
View Article and Find Full Text PDFWe assessed the anthropometric characteristics of symmetric (SGA-S) and asymmetric (SGA-A) term newborns and describe their subcutaneous fat differences. We assessed perinatal data, maternal characteristics and anthropometric variables (including skinfold thicknesses) in 139 small for gestational age (SGA) term infants, classified as symmetric and asymmetric according to their ponderal index (using the 10(th) percentile as the cut-off criterion). Despite an overall small body size and lower amounts of subcutaneous fat than the reference population, SGA-S term newborns showed a proportionate body fat distribution and SGA-A were thinner and had a lower percentage of central subcutaneous fat than SGA-S.
View Article and Find Full Text PDFBackground: Tobacco smoking during pregnancy alters neurodevelopment. Optical coherence tomography (OCT) provides precise measurements of the retinal nerve fiber layer (RNFL), which forms part of the central nervous system.
Aims: To assess using the OCT how smoking during pregnancy would affect optic nerve development as detected in human offspring.