Publications by authors named "Sofia T Rocha"
The prevalence of motility-related genes within the human oral microbiota.
Microbiol Spectr
January 2025
Article Synopsis
- The human oral and nasal microbiota consists of around 770 cultivable bacterial species, with over 2,000 genome sequences available in the expanded Human Oral Microbiome Database (eHOMD).
- Researchers created a Python tool called HOMDscrape to help retrieve and analyze data regarding bacterial motility from eHOMD.
- The study focused on the evolutionary relationships of motile bacteria, specifically examining the type 9 secretion system (T9SS) and its role in bacterial motility, which may influence how these bacteria coexist in the human oral microbiota.
The recently discovered Type 9 Secretion System (T9SS) is present in bacteria of the Fibrobacteres-Bacteroidetes-Chlorobi superphylum, which are key constituents of diverse microbiomes. T9SS is instrumental in the extracellular secretion of over 270,000 proteins, including peptidases, sugar hydrolases, metal ion-binding proteins, and metalloenzymes. These proteins are essential for the interaction of bacteria with their environment.
View Article and Find Full Text PDFThe human oral and nasal microbiota contains approximately 770 cultivable bacterial species. More than 2000 genome sequences of these bacteria can be found in the expanded Human Oral Microbiome Database (eHOMD). We developed HOMDscrape, a freely available Python software tool to programmatically retrieve and process amino acid sequences and sequence identifiers from BLAST results acquired from the eHOMD website.
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