Publications by authors named "Sofia Pimentel"
Introduction And Importance: Spontaneous perforation of the biliary tree, resulting in retroperitoneal biloma in adults is an extremely rare condition, and may unfold to a potentially fatal outcome, particularly when the diagnosis and definitive treatment are delayed.
Case Presentation: We report a case of a 69-year-old male who presented to the emergency room with abdominal pain, localized to the right quadrants, associated with jaundice and dark-coloured urine. Abdominal imaging including CT scan, ultrasound and magnetic resonance cholangiopancreatography (MRCP) revealed a retroperitoneal fluid collection, a distended gallbladder with wall thickening and lithiasis, as well as a dilated common bile duct (CBD) with choledocholithiasis.
External validity of clinical trials with diverse trastuzumab-based chemotherapy regimens in advanced gastroesophageal adenocarcinoma: data from the AGAMENON-SEOM registry.
Ther Adv Med Oncol
June 2021
Article Synopsis
- * A study involving 594 patients assessed various treatment regimens and found that those using FOLFOX with trastuzumab had a significantly longer median exposure to the drug and better overall survival rates compared to traditional ToGA regimens.
- * Results indicated that patients with HER2 IHC 3+ tumors responded better to treatment, while FOLFOX-trastuzumab showed promising outcomes, especially for subtypes traditionally less responsive to trastuzumab, warranting further investigation. *
Research into cancer-associated thrombosis (CAT) entails managing dynamic data that pose an analytical challenge. Thus, methods that assume proportional hazards to investigate prognosis entail a risk of misinterpreting or overlooking key traits or time-varying effects. We examined the AGAMENON registry, which collects data from 2,129 patients with advanced gastric cancer.
View Article and Find Full Text PDFBackground: Trastuzumab significantly improves overall survival (OS) when added to cisplatin and fluoropyrimidine as a treatment for HER2-positive advanced gastric cancers (AGC). The aim of this study was to evaluate the impact of the gradual implementation of HER2 testing on patient prognosis in a national registry of AGC.
Methods: This Spanish National Cancer Registry includes cases who were consecutively recruited at 28 centers from January 2008 to January 2016.
Article Synopsis
- The text discusses various research studies focusing on health topics, including health literacy in adolescents and the impact of walking programs on individuals with schizophrenia.
- It also covers innovative medical practices, safety culture in patient care, and the psychological effects experienced by emergency crews after disasters.
- Additionally, it highlights issues such as musculoskeletal disorders in midwives, negative childhood experiences affecting adolescent mental health, and studies on vaccination timing and assessments in elderly care.