Publications by authors named "Sofia Meyer Zu Reckendorf"
Article Synopsis
- Peripheral nerve injuries can lead to the formation of neuromas, which are abnormal growths at the injury site that can stop nerves from healing properly.
- Researchers studied human neuroma tissue and compared it to healthy nerves from the same person to understand what happens at the injury site over time (1-13 months after injury).
- They found that even though the nerve repair cells called Schwann cells were present, they were in a "repair mode" and different from healthy cells, with signs of inflammation and reduced ability to form myelin, which is important for nerve function.
In postmitotic neurons, several tumor suppressor genes (TSGs), including p53, Rb, and PTEN, modulate the axon regeneration success after injury. Particularly, PTEN inhibition is a key driver of successful CNS axon regeneration after optic nerve or spinal cord injury. In contrast, in peripheral neurons, TSG influence in neuronal morphology, physiology, and pathology has not been investigated to the same depth.
View Article and Find Full Text PDFMammals differ in their regeneration potential after traumatic injury, which might be caused by species-specific regeneration programs. Here, we compared murine and human Schwann cell (SC) response to injury and developed an ex vivo injury model employing surgery-derived human sural nerves. Transcriptomic and lipid metabolism analysis of murine SCs following injury of sural nerves revealed down-regulation of lipogenic genes and regulator of lipid metabolism, including Pparg (peroxisome proliferator-activated receptor gamma) and S1P (sphingosine-1-phosphate).
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