Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis.

Objective: To determine the impact of cervical excision for cervical intraepithelial neoplasia on fertility and early pregnancy outcomes.

Design: Systematic review and meta-analysis of cohort studies.

Data Sources: Medline and Embase.

Histology verification demonstrates that biospectroscopy analysis of cervical cytology identifies underlying disease more accurately than conventional screening: removing the confounder of discordance.

Background: Subjective visual assessment of cervical cytology is flawed, and this can manifest itself by inter- and intra-observer variability resulting ultimately in the degree of discordance in the grading categorisation of samples in screening vs. representative histology. Biospectroscopy methods have been suggested as sensor-based tools that can deliver objective assessments of cytology.

Large loop excision of the transformation zone and cervical intraepithelial neoplasia: a 22-year experience.

Aim: To review the 22-year experience of the use of large loop excision of the transformation zone (LLETZ) for the treatment of cervical intraepithelial neoplasia (CIN).

Design: Retrospective observational study.

Setting: University Hospital of Ioannina, Greece.