A nuclear redox sensor modulates gene activation and switching in .

The virulence of , which causes the deadliest form of human malaria, is attributed to its ability to evade the human immune response. These parasites "choose" to express a single variant from a repertoire of surface antigens called PfEMP1, which are placed on the surface of the infected red cell. Immune evasion is achieved by switches in expression between genes, each encoding a different EMP1 variant.