Publications by authors named "Sofia Girald Berlingeri"
Article Synopsis
- Research indicates that despite existing therapies, the outlook for patients with refractory or recurrent rhabdomyosarcoma (RMS) remains poor, prompting exploration of differentiation-inducing treatments.
- In preclinical models of RAS-mutant PAX fusion-negative RMS, MEK1/2 inhibition has shown potential to encourage differentiation, slow tumor growth, and extend survival, although responses are often temporary.
- The study identifies ASAP1 and ARF1 as crucial regulators in promoting differentiation in FN-RMS cells, revealing that targeting these molecules may enhance treatment strategies by affecting key transcriptional regulators, such as WWTR1 (TAZ).
ERK phosphorylation is dependent on cell adhesion in a subset of pediatric sarcoma cell lines.
Biochim Biophys Acta Mol Cell Res
August 2022
Article Synopsis
- Osteosarcoma (OS) and Pax-Foxo1 fusion negative rhabdomyosarcoma (FN-RMS) are serious pediatric cancers known for their poor outcomes, especially in advanced stages, with a focus on the role of actin binding proteins in worsening prognosis.
- The study investigates how integrin adhesion complexes (IACs) and actin dynamics influence ERK activation in different cell lines from OS and FN-RMS, revealing varied adhesion-dependent responses between the two cancer types.
- Findings indicate that ERK phosphorylation is not consistently affected by adhesion in OS cells, while in FN-RMS, adhesion boosts ERK activation and points to distinct mechanisms of cell signaling that differ from existing models observed in other cancers.
Triple negative breast cancer (TNBC) remains a serious health problem with poor prognosis and limited therapeutic options. To discover novel approaches to treat TNBC, we screened cholera toxin (CT) and the members of the bacterial type II heat-labile enterotoxin family (LT-IIa, LT-IIb, and LT-IIc) for cytotoxicity in TNBC cells. Only LT-IIc significantly reduced viability of the TNBC cell lines BT549 and MDA-MB-231 (IC = 82.
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- ADP-ribosylation factors (Arfs) are part of the Ras GTPase superfamily and play a crucial role in cell processes by cycling between GDP-bound and GTP-bound states, influenced by GAPs and GEFs.
- Arf GAPs are found in integrin adhesion complexes, which are essential for various cell functions like proliferation and migration, making them significant in both normal physiology and cancer.
- The review explores how different Arf GAPs, like GIT1, GIT2, and AGAP2, contribute to the formation, maturation, and dynamics of integrin adhesion complexes, showcasing their diverse mechanisms and functions.