Publications by authors named "Sofia Figueiras"
Copper(II)-based complexes are promising candidates as anti-cancer agents due to their ability to target cancer cells. Here we describe the synthesis and characterization of two copper(II) thiosemicarbazone complexes with the ligands 4-(dimethylamino)benzaldehyde N4-methylthiosemicarbazone (HL) and 4-(dimethylamino)benzaldehyde N4-(4-(dimethylamino)phenylthiosemicarbazone (HL) and general formula [Cu(L)]. The complexes show stability in aqueous solution with 1 % of DMSO that allows to stablish its solution profile in biological buffers.
View Article and Find Full Text PDFGastric cancer prognosis is still notably poor despite efforts made to improve diagnosis and treatment of the disease. Chemotherapy based on platinum agents is generally used, regardless of the fact that drug toxicity leads to limited clinical efficacy. In order to overcome these problems, our group has been working on the synthesis and study of trans platinum (II) complexes.
View Article and Find Full Text PDFArticle Synopsis
- The S protein of SARS-CoV-2 contributes to premature vascular aging and endothelial cell senescence, which are significant risk factors for cardiovascular diseases related to COVID-19.
- In human umbilical vein endothelial cells, the S protein increases markers of cellular senescence and DNA damage while decreasing protective proteins, leading to impaired endothelial function.
- Pharmacological interventions, like inhibiting the NLRP3 inflammasome or supplementing protective proteins, can counteract the harmful effects of the S protein, suggesting potential therapeutic strategies for managing COVID-19-related vascular complications.