The Mediating Role of Social Support on COVID-19 Concern and Self-Rated Physical Health of Older Adults in the United States.

The COVID-19 significantly impacted older adults, worsening their physical health and social connectedness. This study examined whether social support mediates the correlation between COVID-19 concerns and self-rated physical health (SRPH) using data from 2672 participants (aged 50-99) in the NSHAP COVID-19 sub-study (2019-20). Mediation analysis revealed that COVID-19 concerns significantly predicted lower perceived social support (b = -0.

Structural equation modeling of factors associated with nursing students' professionalism during the COVID-19 pandemic.

This study aimed to determine the factors associated with nursing professionalism among Korean nursing students. This cross-sectional study was carried out using a convenient sample comprising 247 students enrolled in a four-year Bachelor of Science Nursing program from September 6-27, 2021. A self-reported structured questionnaire was employed to explore the relationships among ego-resilience, self-leadership, clinical learning environment, academic satisfaction, clinical competency, and nursing professionalism by utilizing structural equation modeling.

Eutectic Formation of Naproxen with Some Dicarboxylic Acids.

Eutectic formation with additives is one of the established methods to improve the dissolution behaviors of active pharmaceutic ingredients (APIs). The improvement is mainly due to the increase in the surface area for dissolution, which originates from the finely divided micro-domains generated through the phase separation of the miscible liquid components upon solidification. The present study is to identify eutectic-forming additives for naproxen (NPX), a class II API of the biopharmaceutical classification system.

Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation.

Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs. Cocrystal formation is one of the methods to alter the physicochemical properties of APIs, but its dissolution behavior in biorelevant media has been scrutinized only in recent years. We investigated the combined strategy of cocrystallization and eutectic formation in this regard and utilized the cocrystal model system of naproxen and three pyridinecarboxamide isomers.