Cysteine-rich matricellular protein improves callus regenerate in a rabbit trauma model.

Purpose: Open fractures with severe soft-tissue trauma are predisposed to poor bone healing. The vital coupling between osteo- and angiogenesis is disturbed. Cysteine-rich protein 61 (CYR61) is an angiogenic inducer promoting vascularisation.

VEGF improves skeletal muscle regeneration after acute trauma and reconstruction of the limb in a rabbit model.

Background: Complicated tibial fractures with severe soft tissue trauma are challenging to treat. Frequently associated acute compartment syndrome can result in scarring of muscles with impaired function. Several studies have shown a relationship between angiogenesis and more effective muscle regeneration.