Survived traumatic hemipelvectomy with salvage of the limb in a 14 months old toddler.

We report on a 14 months old toddler who sustained a traumatic hemipelvectomy by being crushed between a car and a stone wall. After stabilization in the resuscitation room he was treated operatively by laparotomy, osteosynthesis of the pelvic ring, reconstruction of the both external iliac vessels and the urethra and reposition of the testicles. After 66 days he was discharged into rehabilitation.

Biomechanical analysis of different osteosyntheses and the combination with bone substitute in tibial head depression fractures.

Background: Tibial head depression fractures demand a high level of fracture stabilization to prevent a secondary loss of reduction after surgery. Elderly individuals are at an increased risk of developing these fractures, and biomechanical investigations of the fractures are rare. Therefore, the aim of this study was to systematically analyze different types of osteosyntheses in combination with two commonly used bone substitutes.

Bone substitute first or screws first? A biomechanical comparison of two operative techniques for tibial-head depression fractures.

Background: The aim of this study was to investigate a drillable and injectable bone substitute (calcium phosphate cement) and the operative technique enabled by the drillable option in a new biomechanical fracture model for tibial depression fractures in synthetic bones.

Materials And Methods: Lateral depression fractures of the tibial plateau (AO 41-B2, Schatzker III) were created in a biomechanical fracture model in three different synthetic bones (Sawbone 3401, Synbone 1110/1116). Reproducible fractures were generated employing Synbone 1110, which exhibited a comparable strength to human osteoporotic bones and was used for the further experiments.

Clinical outcome and changes in gait pattern after pilon fractures.

Purpose: Axial burst fractures of the distal tibia are challenging to treat and often lead to restricted function of the lower limb. The purpose of this study was to investigate the clinical outcome and changes in gait pattern in such patients.

Methods: Thirty-five patients in a level 1 trauma centre were followed up clinically and by gait analysis.

Cysteine-rich matricellular protein improves callus regenerate in a rabbit trauma model.

Purpose: Open fractures with severe soft-tissue trauma are predisposed to poor bone healing. The vital coupling between osteo- and angiogenesis is disturbed. Cysteine-rich protein 61 (CYR61) is an angiogenic inducer promoting vascularisation.

VEGF improves skeletal muscle regeneration after acute trauma and reconstruction of the limb in a rabbit model.

Background: Complicated tibial fractures with severe soft tissue trauma are challenging to treat. Frequently associated acute compartment syndrome can result in scarring of muscles with impaired function. Several studies have shown a relationship between angiogenesis and more effective muscle regeneration.

A contoured locking plate for distal fibular fractures in osteoporotic bone: a biomechanical cadaver study.

Objective: Fixation of ankle fractures in elderly patients is associated with reduced stability conditioned by osteoporotic bone. Therefore, fixation with implants providing improved biomechanical features could allow a more functional treatment, diminish implant failure and avoid consequences of immobilisation.

Materials And Methods: In the actual study, we evaluated a lateral conventional contoured plate with a locking contoured plate stabilising experimentally induced distal fibular fractures in human cadavers from elderly.

Subtrochanteric fracture: a rare but severe complication after screw fixation of femoral neck fractures in the elderly.

Cannulated screw fixation is a minimal invasive technique to treat undisplaced femoral neck fractures. It is the preferred method in elderly patients who often suffer co-morbidities. There is scarce literature on subtrochanteric femoral fracture as a complication of cannulated screw fixation of a femoral neck fracture.

Downregulation of beta-catenin and transdifferentiation of human osteoblasts to adipocytes under estrogen deficiency.

Background And Aim: Postmenopausal osteoporosis, caused by estrogen deficiency, is characterized by the structural deterioration of bone accompanied by an increase in bone marrow adipocytes. Transgenic animal models have shown that there is a reciprocal relationship between osteoblastogenesis and adipogenesis in vivo. The present study investigated whether the estrogen and the canonical Wnt signaling pathways are linked together and regulate the phenotype and function, differentiation and proliferation of human osteoblasts using an in vitro estrogen-deficiency model.