Publications by authors named "Sodiq A Hameed"
In the human and veterinary fields, oral vaccines generate considerable interest. In dogs, these vaccines are newly developed, and understanding their mechanisms is crucial. Mesenteric lymph nodes (MLNs) and Peyer's patches (PPs) are important sites for gastrointestinal mucosal induction, yet canine MLNs lack sufficient information.
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- Oral vaccination is effective for stimulating immune responses, with GALT and Peyer's patches being key players; however, our knowledge about these systems in dogs is still limited.
- The research involved advanced techniques like immunofluorescence, flow cytometry, and single-cell RNA sequencing to study canine Peyer's patches and their immune cell populations.
- The development of a specific antibody targeting canine M cells will assist in understanding how antigens enter the dog's GALT, providing insights for future studies on dog immune responses and diseases.
In recent years, there has been ample evidence illustrating the effect of microbiota on gut immunity, homeostasis, and disease. Most of these studies have engaged more efforts in understanding the role of the bacteriome in gut mucosal immunity and disease. However, studies on the virome and its influence on gut mucosal immunity and pathology are still at infancy owing to limited metagenomic tools.
View Article and Find Full Text PDFThe mRNA vaccine platform has offered the greatest potential in fighting the COVID-19 pandemic owing to rapid development, effectiveness, and scalability to meet the global demand. There are many other mRNA vaccines currently being developed against different emerging viral diseases. As with the current COVID-19 vaccines, these mRNA-based vaccine candidates are being developed for parenteral administration via injections.
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