Radiation-induced rectovaginal fistulas in locally advanced gynaecological malignancies-new patients, old problem?

Purpose: Radiation-induced rectovaginal fistula (RI-RVF) is a chronic and serious condition with a significant influence on quality of life. The aim of this study is to evaluate the results of surgical treatment of rectovaginal fistulas of patients previously undergoing radiotherapy.

Methods: Fifty patients treated in the Gynaecological Radiotherapy Unit for gynaecologic malignancy and in the Department of General and Colorectal Surgery for RI-RVF between 2003 and 2013 were enrolled into a prospectively maintained database and underwent regular follow-up examinations in an outpatient clinic, during which surgical outcomes were assessed.

Highly conformal CT based surface mould brachytherapy for non-melanoma skin cancers of earlobe and nose.

Purpose: Brachytherapy (BT), due to rapid dose fall off and minor set-up errors, should be superior to external beam radiotherapy (EBRT) for treatment of lesions in difficult locations like nose and earlobe. Evidences in this field are scarce. We describe computed tomography (CT) based surface mould BT for non-melanoma skin cancers (NMSC), and compare its conformity, dose coverage, and tissue sparing ability to EBRT.

Interdisciplinary treatment of the patient with adenoid cystic carcinoma of the Bartholin's gland resulting in 15 years' survival: a case report and review of literature.

Carcinoma of the Bartholin's gland is very rare, comprises below 2% of Bartholin's gland lesions and adenoid cystic carcinoma (ADC) is one of the most uncommon variants and accounts for 10-15% of Bartholin's gland malignancies. There is no consensus on treatment of ADC of the Bartholin's gland: reported cases were treated with local excision or vulvectomy with or without lymphadenectomy followed or not by radiotherapy. The survival of patients varies significantly, so we present a case of interdisciplinary treatment of ADC resulting in 15 years' survival.

Comparison of prognosis in patients with endometrioid endometrial cancer staged IB in FIGO 1988 and 2009 classifications.

Purpose: Since 2009 the new FIGO Staging System of endometrial cancer, which changed the previous FIGO 1988 Staging System, has been in use. The aim of the study was to compare prognosis in patients with endometrioid endometrial cancer at stage IB of the 2009 FIGO Staging System and of the 1988 FIGO Staging System.

Methods: We analyzed 173 patients: 108 patients (group A) at stage IB in FIGO 1988 Staging System, and 68 patients (group B) at stage IB in FIGO 2009 Staging System from 262 consecutive endometrioid endometrial cancer patients.

Clinical significance of serum CA-125 and soluble tumor necrosis factor receptor type I in cervical adenocarcinoma patients.

Hypothesis: The purpose of this study was to answer the question whether the measurement of the pretreatment tumor markers and cytokine levels would be of clinical use in patients with cervical adenocarcinoma.

Methods: CA-125, carcinoembryonic antigen (CEA), and squamous cell carcinoma (SCC), as well as interleukin 6 (IL-6), IL-8, vascular endothelial growth factor, IL-1 receptor antagonist, soluble tumor necrosis factor receptor type I (sTNF RI), and sTNF RII, were assessed in the sera of 120 cervical adenocarcinoma patients.

Results: CA-125 presented a better diagnostic sensitivity than did CEA and SCC, whereas the concentration of most cytokines, except for sTNF RII, revealed higher sensitivity, than did the standard tumor markers.

Significance of hypoxia in uterine cervical cancer. Multicentre study.

Purpose: The aim of the study was to evaluate hypoxia markers (VEGF, GLUT-1, and HIF-1alpha) in cervical cancer tissue depending on staging (FIGO) and grading. We also analyzed the adverse effects of radiotherapy according to expression levels of hypoxic markers in the studied tissue.

Material And Methods: Expression of hypoxia-inducible factor-1alpha (HIF-1alpha), glucose transporter 1 (GLUT-1) and vascular endothelial growth factor (VEGF, also known as proangiogenic factor) were estimated in biopsy or surgical specimens from 106 patients diagnosed with uterine cervical cancer.

Preliminary results of mitomycin C local application as post-treatment prevention of vaginal radiation-induced morbidity in women with cervical cancer.

Purpose: To determine the usefulness of local mitomycin C application in the prophylaxis of vaginal narrowing after irradiation.

Material And Methods: 31 patients with advanced cervical cancer qualified for the study. They underwent brachytherapy with iridium-192 isotope and external beam therapy with linear accelerators.

[Preoperative high-dose brachytherapy in cases of endometrial carcinoma--preliminary assessment of outcomes and safety].

Introduction: Rising incidence of endometrial carcinoma provokes searching for the best and the safest treatment method.

Materials And Methods: We included in our observation 35 patients suffering from gynaecologic malignancies. They had been treated in H.

Preoperative brachytherapy in endometrial cancer--proposal of a new clinical protocol.

High-dose rate brachytherapy preoperative treatment has been described. The proposal of a protocol contains an outline of patient qualifications for this kind of treatment, as well as necessary laboratory and diagnostic imaging examinations. Methods of brachytherapy (low-dose rate and high-dose rate), methods of surgery and postoperative management of patients with endometrial cancer are discussed.

Vaginal bleeding as a first symptom of malignant lymphoma: case reports, diagnosis and successful treatment.

Uncommon pathologic changes of the uterine cervix are rare but not impossible. Described cases of cervical lymphoma indicate the necessity of great attention and careful diagnosis. A watchful examination, imaging procedures and detailed histopathologic findings are of crucial importance in treatment planning.

[Stereotactic biopsy and brachytherapy in the diagnostics and treatment of brain tumors--preliminary report].

Promising results have been obtained using brachytherapy in the treatment of brain tumors. Between November 99 and August 2000, 28 patients with brain tumors (15 newly diagnosed gliomas, 11 recurrent gliomas, 2 metastases) underwent implantation of temporary iridium 192 sources with stereotactic technique. This group received external beam radiation therapy (45 Gy) following implantation.

[The role of preoperative brachytherapy in the treatment of early invasive cervical cancer].

The role of preoperative brachytherapy in the treatment of cervical cancer are discussed. Authors described a group of 45 patients with preliminary diagnosis of Io and IIo A sec FIGO tumour. Qualification system to combined treatment and diagnostic procedure are described.

[Electro-conization of the uterine cervix in the Department of Oncologic Gynecology in Lodz in the years 1968-1987].

Considering the carcinoma incidence rate in women population the cervical carcinoma takes the second place. The diagnosis and proper treatment of the precancerous conditions and the preinvasive carcinoma cause the reduction of invasive cancer incidence rate. In this paper, it has been presented 20-years experience concerning cervical electro-conization in above mentioned department.