Influence of Loading Mode on the Biaxial Stress-Strain Curve at Hydraulic Bulge Test.

Stress-strain curves are generally a very important material characteristic. For example, in numerical simulations, especially in sheet metal forming, stress-strain curves represent one of the most important data inputs. However, there is quite a wide range of parameters that influence their outline under the chosen technological conditions and, therefore, must always be taken into account.

AQUA-GAPS/MONET-Derived Concentrations and Trends of PAHs and Polycyclic Musks across Global Waters.

Polycyclic aromatic hydrocarbons (PAHs), released from petrogenic, pyrogenic or diagenetic sources (degradation of wood materials), are of global concern due to their adverse effects, and potential for long-range transport. While dissolved PAHs have been frequently reported in the literature, there has been no consistent approach of sampling across water bodies. Passive samplers from the AQUA/GAPS-MONET initiative were deployed at 46 sites (28 marine and 18 freshwater), and analyzed for 28 PAHs and six polycyclic musks (PCMs) centrally.

Analysis of TRIP Steel HCT690 Deformation Behaviour for Prediction of the Deformation Process and Spring-Back of the Material via Numerical Simulation.

This paper deals with the analysis of TRIP steel HCT690 deformation behaviour. The mechanical properties and deformation characteristics of the tested material are determined using selected material tests and tests that consider the required stress states used to define the yield criterion boundary condition and subsequent deformation behaviour in the region of severe plastic deformation. The measured data are subsequently implemented in the numerical simulation of sheet metal forming, where they are used as input data for the computational process in the form of a selected material model defining the yield criterion boundary and, furthermore, the material hardening law during deformation of the material.

Length-Dependent Translation Efficiency of ER-Destined Proteins.

Gene expression is a fundamental process that enables cells to produce specific proteins in a timely and spatially dependent manner. In eukaryotic cells, the complex organization of the cell body requires precise control of protein synthesis and localization. Certain mRNAs encode proteins with an N-terminal signal sequences that direct the translation apparatus toward a specific organelle.

Comparison of the Structure, Mechanical Properties and Effect of Heat Treatment on Alloy Inconel 718 Produced by Conventional Technology and by Additive Layer Manufacturing.

The nickel-iron-based alloy Inconel 718 is a progressive material with very good mechanical properties at elevated and lower temperatures. It is used both as wrought and cast alloys as well as material for additive manufacturing technologies. This is the reason why it has received so much attention, as supported by numerous publications.

Bioanalytical and chemical characterization of organic micropollutant mixtures in long-term exposed passive samplers from the Joint Danube Survey 4: Setting a baseline for water quality monitoring.

Monitoring methodologies reflecting the long-term quality and contamination of surface waters are needed to obtain a representative picture of pollution and identify risk drivers. This study sets a baseline for characterizing chemical pollution in the Danube River using an innovative approach, combining continuous three-months use of passive sampling technology with comprehensive chemical (747 chemicals) and bioanalytical (seven in vitro bioassays) assessment during the Joint Danube Survey (JDS4). This is one of the world's largest investigative surface-water monitoring efforts in the longest river in the European Union, which water after riverbank filtration is broadly used for drinking water production.

Passive-Sampler-Derived PCB and OCP Concentrations in the Waters of the World─First Results from the AQUA-GAPS/MONET Network.

Persistent organic pollutants (POPs) are recognized as pollutants of global concern, but so far, information on the trends of legacy POPs in the waters of the world has been missing due to logistical, analytical, and financial reasons. Passive samplers have emerged as an attractive alternative to active water sampling methods as they accumulate POPs, represent time-weighted average concentrations, and can easily be shipped and deployed. As part of the AQUA-GAPS/MONET, passive samplers were deployed at 40 globally distributed sites between 2016 and 2020, for a total of 21 freshwater and 40 marine deployments.

Experimental and Numerical Analysis of the Residual Stresses in Seamed Pipe in Dependence on Welding and Metal Forming.

Concerning the increasingly widespread utilization of the finite element method (FEM), the concept of the so-called virtual factory is also gaining ground, and not only in the engineering industry. This approach does not use numerical simulations of individual production technologies separately but treats the entire production process as a chain of interrelated technologies. Thus, the output data from one technology is taken as input data for the following technology.

Online teaching of practical classes under the Covid-19 restrictions.

COVID -19 pandemic and its restrictions bring new challenges to all aspects and phases of higher education. At universities, new remote formats have been developed and deployed for lectures and laboratory exercises. This article addresses challenges and introduces the new experience with lectures and laboratory classes during the pandemic time at the Department of Measurement of the Czech Technical University in Prague, Faculty of Electrical Engineering.

Occurrence, sources, and spatial variation of POPs in a mountainous tropical drinking water supply basin by passive sampling.

Persistent organic pollutants (POPs) are widely distributed along the world and their levels in surface waters may pose a risk to human health due to consumption of contaminated water or fish long-term exposure to contaminated water. The occurrence of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in the Piedras river (Colombia) is a problem of serious concern since freshwater is conducted to a drinking water supply system that provides more than 3 million users. In this research, we deployed silicone rubber membranes as passive samplers in two sampling campaigns at seven sampling stations selected along the river, to assess sources and spatial variation of POPs.

Acute myeloid leukemia with variant t(8;10;21).

The t(8;21)(q22;q22) is one of the most common chromosomal abnormalities in acute myeloid leukemia (AML). Approximately 3-4% of AML cases are associated with additional chromosomal abnormalities. Their impact on the prognosis of the disease remains to be established.

Alumina Manufactured by Fused Filament Fabrication: A Comprehensive Study of Mechanical Properties and Porosity.

This article deals with a comprehensive study of the processing and mechanical properties of the ceramic material Al2O3 on Fused Filament Fabrication technology (FFF). It describes the basic input analyses of the material, such as TGA, FTIR, and MVR. These analyses enabled the design and testing of process parameters for the 3D printing of parts.

Performance comparison of silicone and low-density polyethylene as passive samplers in a global monitoring network for aquatic organic contaminants.

Contamination with hydrophobic organic compounds (HOCs) such as persistent organic pollutants negatively affects global water quality. Accurate and globally comparable monitoring data are required to understand better the HOCs distribution and environmental fate. We present the first results of a proof-of-concept global monitoring campaign, the Aquatic Global Passive Sampling initiative (AQUA-GAPS), performed between 2016 and 2020, for assessing trends of freely dissolved HOC concentrations in global surface waters.

Online teaching at CTU in Prague aka university under COVID restrictions.

Covid-19 related restrictions bring new challenges to all aspects and phases of higher education. At universities, new remote formats are deployed or even developed both for lectures and laboratory exercises. This article addresses new challenges and describes the experience with lessons during the pandemic time at the Department of Measurement of the Czech Technical University in Prague, Faculty of Electrical Engineering.

Possibilities to Use Physical Simulations When Studying the Distribution of Residual Stresses in the HAZ of Duplex Steels Welds.

Dual phase steels combine very good corrosion resistance with relatively high values of mechanical properties. In addition, they can maintain good plastic properties and toughness at both room temperature and lower temperatures as well. Despite all the advantages mentioned above, their utility properties can be reduced by technological processing, especially by the application of the temperature cycles.

Characteristics of Porous Aluminium Materials Produced by Pressing Sodium Chloride into Their Melts.

The paper deals with research related to the production of metal cellular aluminium systems, in which production is based on the application of sodium chloride particles. In this paper, the properties of porous aluminium materials that were produced by an unconventional method-by pressing salt particles into the melt of aluminium alloy-are described. The new methodology was developed and verified for the production of these materials.

Acute icteric hepatitis as the first isolated symptom of COVID-19.

Patients with COVID-19 may be asymptomatic or present with extrarespiratory symptoms, such as liver injury. It has been reported that 22.5%-46.

Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment.

Cellular immunotherapy is becoming a new pillar in cancer treatment after recent striking results in different clinical trials with chimeric antigen receptor T cells. However, this innovative therapy is not exempt from challenges such as off-tumor toxicity, tumor recurrence in heterogeneous tumors, and affordability. To surpass these limitations, we exploit the unique anti-tumor characteristics of natural killer (NK) cells.

Dynamic passive sampling of hydrophobic organic compounds in surface seawater along the South Atlantic Ocean east-to-west transect and across the Black Sea.

Mapping of hydrophobic organic compounds (HOCs) in surface seawater on an east-to-west transect of the South Atlantic Ocean (SAO) and across the Black Sea (BS) in 2016 was performed by a dynamic passive sampling device containing silicone-based passive samplers. In SAO as well as in BS the measurements confirmed freely dissolved concentrations of polychlorinated biphenyls, DDT and its metabolites, chlorobenzenes, cyclodiene pesticides, and brominated flame retardants in the range of units to low hundreds of pg per litre. The findings indicate that the spatial distribution of HOCs and emerging pollutants in the SAO and the BS is influenced by riverine inputs, ocean currents and atmospheric deposition from continental plumes.

Unraveling the Relationship between the Concentrations of Hydrophobic Organic Contaminants in Freshwater Fish of Different Trophic Levels and Water Using Passive Sampling.

The concentrations of hydrophobic organic compounds (HOCs) in aquatic biota are used for compliance, as well as time and spatial trend monitoring in the aqueous environment (European Union water framework directive, OSPAR). Because of trophic magnification in the food chain, the thermodynamic levels of HOCs, for example, polychlorinated biphenyl congeners, dichlorodiphenyltrichloroethane, and brominated diphenyl ether congeners, in higher trophic level (TL) organisms are expected to be strongly elevated above those in water. This work compares lipid-based concentrations at equilibrium with the water phase derived from aqueous passive sampling () with the lipid-based concentrations in fillet and liver of fish () at different TLs for three water bodies in the Czech Republic and Slovakia.

Leadership Succession Preparedness and Sense of Urgency in Canadian Hospital Pharmacy.

Background: Leadership turnover is unavoidable in all organizations, including hospital pharmacy departments. Succession planning can promote organizational stability, among other benefits.

Objectives: To gather a contemporary, nationwide measure of the level of preparedness for department leadership succession and to gain related insight from a variety of pharmacy leaders.

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in . e.

Proper regulation of germline gene expression is essential for fertility and maintaining species integrity. In the germline, a diverse repertoire of regulatory pathways promote the expression of endogenous germline genes and limit the expression of deleterious transcripts to maintain genome homeostasis. Here we show that the conserved TRIM-NHL protein, NHL-2, plays an essential role in the germline, modulating germline chromatin and meiotic chromosome organization.