Anti-nociceptive effects of magnolol via inhibition of TRPV1/P2Y and TLR4/NF-κB signaling in a postoperative pain model.

Aims: The current study explored the anti-nociceptive activity of magnolol in post-incisional inflammatory nociceptive pain.

Main Methods: Preliminary, the anti-inflammatory, antioxidant, and cytoprotective potential of magnolol were confirmed against hydrogen peroxide (HO)-induced PC12 cells. Next, an in-vivo model of planter incision surgery was established in BALB/c mice.

Hybridization of green synthesized silver nanoparticles with poly(ethylene glycol) methacrylate and their biomedical applications.

In the present research, a rapid, simple and efficient green method is used for the incorporation of silver nanoparticles (AgNPs) into poly(ethylene glycol) methacrylate (PEGMA) to create biocatalysts with excellent properties for pharmaceutical purpose. In the first phase, capped AgNPs (Ca-AgNPs) were prepared using green synthetic approach and in the second phase capped AgNPs were hybridized with poly(ethylene glycol) methacrylate to form PEGMA-AgNPs. Both the virgin (naked or uncapped) and polymer-capped materials were characterized spectroscopically and their results were compared.

Highly dispersive palladium nanoparticle in nanoconfined spaces for heterogeneous catalytic reduction of anthropogenic pollutants.

Pd-containing catalysts are highly promising in catalytic reactions, and their activity severely dependent on the dispersion extent of Pd nanoparticles (Pd NPs) . However, the regulation of Pd NPs size and dispersion degree are now pretty much the agendas. Here we report a facile solid-state fabrication strategy (SSFS) to promote Pd NPs dispersion in the nano environment of as made mesoporous silica KIT-6 (AK) by taking advantage of three critical factors, namely (i) the confined spaces where Pd precursor locate during fabrication, (ii) the interaction between Pd and supports, and (iii) the 3-dimentional (3D) structure of AK.

Unusual Pd nanoparticle dispersion in microenvironment for p-nitrophenol and methylene blue catalytic reduction.

Palladium based catalysts are highly attractive for catalytic reactions. However, the catalytic activity is dependent on the dispersion and size of Pd nanoparticles (NPs). Herein, an efficient strategy is developed to regulate the size and dispersion of Pd NPs in nanoconfined spaces provided by Santa Barbara Amorphous-15 (SBA-15) occluded with template.

Fabrication of 3-D confined spaces with Au NPs: Superior dispersion and catalytic activity.

Gold nanoparticles (Au NPs) as an active noble-metal site have received great attention because of its superior catalytic activity in diverse reactions. However, the activity of Au NPs is strongly dependent on its size and dispersion degree. Therefore, we developed an efficient solid-state reduction (SSR) strategy for the first time to promote the dispersion degree and size of Au NPs in template-occluded KIT-6 (AK) as a support by taking advantage of (i) 3-dimentonal cubic mesoporous structure of support (ii) confined spaces present between template (Pluronic (P) 123) and silica wall of AK where Au NPs locate (iii) interaction of both P123 as template and silica walls of AK with Au NPs highly efficient for Au NPs dispersion and (iv) SSR strategy which avoids competitive adsorption of solvent in the conventional fabrication process.

In situ one-step synthesis of FeO@MIL-100(Fe) core-shells for adsorption of methylene blue from water.

A new route for FeO@MIL-100(Fe) core-shells is proposed via in situ one-step hydrothermal strategy, in which FeO microspheres not only serve as magnetic cores but also provide Fe(III) for MIL-100(Fe) synthesis. The MIL-100(Fe) is uniformly grown as a shell on the surface of FeO, and the shell thickness can be fine-tuned from 73.5 to 148nm by simply controlling the reaction time.

Neuronal function of Tbx20 conserved from nematodes to vertebrates.

The Tbx20 orthologue, mab-9, is required for development of the Caenorhabditis elegans hindgut, whereas several vertebrate Tbx20 genes promote heart development. Here we show that Tbx20 orthologues also have a role in motor neuron development that is conserved between invertebrates and vertebrates. mab-9 mutants exhibit guidance defects in dorsally projecting axons from motor neurons located in the ventral nerve cord.

The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.

The C. elegans pharynx is produced from the embryonic blastomeres ABa and MS. Pharyngeal fate in the ABa lineage is specified by the combined activities of GLP-1/Notch-mediated signals and the TBX-37 and TBX-38 T-box transcription factors.

The forkhead gene family of Caenorhabditis elegans.

The forkhead genes encode a family of transcriptional regulators with important roles in the control of animal development. The genomic sequence has revealed Caenorhabditis elegans has 15 forkhead genes of which six had been experimentally characterised previously. The remaining nine have now been investigated by RNAi and reporter gene expression pattern analysis.