Publications by Sobhy E H El-Nabi

Publications by authors named "Sobhy E H El-Nabi"

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The regulation of HBP1, SIRT1, and SREBP-1c genes and the related microRNAs in non-alcoholic fatty liver rats: The association with the folic acid anti-steatosis.

Muthana Salman Maher A Kamel Sobhy E Hassab El-Nabi Abdel Hamid A Ismail Sami Ullah

PLoS One

April 2022

Article Synopsis

Folic acid is essential for genetic stability and biological functions, and this study investigates its effects on specific microRNAs and gene expressions related to non-alcoholic fatty liver disease (NAFL) in rats.
A group of 50 Wistar rats was divided into control and NAFL groups, with the latter fed a high-fat diet and treated with varying doses of folic acid to assess changes in miRNA profiles and targeted gene expressions.
Results showed that folic acid treatment improved the characteristics of NAFL in a dose-dependent manner by modulating liver microRNAs and their target genes, suggesting potential therapeutic benefits of folic acid for liver health.

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Evaluation of Bax and Bak gene mutations and expression in breast cancer.

Naglaa Mohamed Kholoussi Sobhy E H El-Nabi Nora Nassef Esmaiel Naser Mohamed Abd El-Bary Ahmed F El-Kased

Biomed Res Int

May 2015

Genetic analyses have provided evidence to suggest that Bax and Bak are the essential genes for apoptosis in mammalians cells. This study aimed to search for biomarkers in breast cancer to be used as prognostic markers for the disease. The Bak and Bax genes expressions were analyzed in 23 breast cancer patients by RT-PCR technique.