Metabolomic Analysis, Antiproliferative, Anti-Migratory, and Anti-Invasive Potential of Amlodipine in Lung Cancer Cells.

Background And Objective: Lung cancer stands as the leading cause of cancer-related fatalities worldwide. While chemotherapy remains a crucial treatment option for managing lung cancer in both early-stage and advanced cases, it is accompanied by significant drawbacks, including severe side effects and the development of chemoresistance. Overcoming chemoresistance represents a considerable challenge in lung cancer treatment.

Experimental and Theoretical Analysis of Dopamine Polymerization on the Surface of Cellulose Nanocrystals and Its Reinforcing Properties in Cellulose Acetate Films.

The study of natural materials inspires sustainable innovations, with biomimetics excelling in surface modification. Polydopamine (PDA) offers a promising approach for modifying cellulose nanocrystals (CNC), enhancing their compatibility with hydrophobic polymers by improving interfacial adhesion. In this work, the modification of CNC with PDA (CNC@PDA) significantly enhanced the compatibility between the nanocargoes and the cellulose acetate (CA) matrix.

Socioeconomic profile and environmental perception of Amazon beach users about solid waste.

Studies on environmental perception can contribute to managing solid waste on beaches, as they elucidate the nuances of the interaction between humans and the environment, highlighting the necessary transformations aligned with user preferences. The objective was to determine the socioeconomic profile of users and identify these actors environmental perceptions of solid waste of bathers on the beaches of Rio Negro and identify their environmental perception about the incorrect disposal of solid waste in these environments. Interviews were conducted on Ponta Negra, Lua, Tupé and Paricatuba beaches.

Metabolomics insights into doxorubicin and 5-fluorouracil combination therapy in triple-negative breast cancer: a xenograft mouse model study.

Background: Breast cancer is one of the most prevalent malignancies and a leading cause of death among women worldwide. Among its subtypes, triple-negative breast cancer (TNBC) poses significant clinical challenges due to its aggressive behavior and limited treatment options. This study aimed to investigate the effects of doxorubicin (DOX) and 5-fluorouracil (5-FU) as monotherapies and in combination using an established MDA-MB-231 xenograft model in female BALB/C nude mice employing advanced metabolomics analysis to identify molecular alterations induced by these treatments.

Methicillin-Resistant : The Shifting Landscape in the United Arab Emirates.

Background: Methicillin-resistant (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity in the clonal complexes (CCs) identified. The COVID-19 pandemic, with its increased hospitalization rates and antibiotic use, may have further influenced MRSA's genetic evolution and epidemiology in the country.

Medwakh smoking induces alterations in salivary proteins and cytokine expression: a clinical exploratory proteomics investigation.

Background: Medwakh smoking has radically expanded among youth in the Middle East and around the world. The rising popularity of medwakh/dokha usage is linked to the onset of several chronic illnesses including cardiovascular diseases and cancers. Medwakh smoking is reported to increase the risk of inflammation in the lower respiratory tract owing to oxidative burden.

Perceptions of Machine Learning among Therapists Practicing Applied Behavior Analysis: A National Survey.

Unlabelled: Collecting data and logging behaviors of clients who have autism spectrum disorder (ASD) during applied behavior analysis (ABA) therapy sessions can be challenging in real time, especially when the behaviors require a rapid response, like self-injury or aggression. Little information is available about the automation of data collection in ABA therapy, such as through machine learning (ML). Our survey of ABA therapists nationally revealed mixed levels of familiarity with ML and generally neutral responses to statements endorsing the benefits of ML.

Estrogen-mediated inhibition of purine metabolism and cell cycle arrest as a novel therapeutic approach in colorectal cancer.

Purine metabolism is upregulated in various cancers including colorectal cancer (CRC). While previous work has elucidated the role of estrogen (E2) in metabolic reprogramming and ATP production, the effect of E2 on purine metabolism remains largely unknown. Herein, the impact of E2 signalling on purine metabolism in CRC cells was investigated using metabolome and transcriptome profiling of cell extracts derived from E2-treated HCT-116 cells with intact or silenced estrogen receptor alpha (ERα).

Nutritional status and changes in muscle and adipose tissue determined by computed tomography as predictors of mortality in hospitalized patients.

The aim of the present study was to investigate whether nutritional status and changes in muscle and adipose tissue determined by computed tomography are predictors of mortality in hospitalized patients. This was a prospective cohort study involving patients ≥ 20 years of age hospitalized in a public hospital. Sociodemographic and clinical variables were collected from electronic medical records.

Multi-omics analysis revealed significant metabolic changes in brain cancer cells treated with paclitaxel and/or topotecan.

Glioblastoma (GBM) stands as the most common primary malignant brain tumor. Despite the best standard therapies, GBM survivors have a brief survival time, about 24 months on average. The treatment is troublesome because the cancer cells may not respond well to specific therapies as they grow within an extensive network of blood vessels.

Exploring the influences of resource limitation and plant aging on pollen development in Azorella nivalis Phil. (Apiaceae), a long-lived high-Andean cushion plant.

Angiosperm pollen, the male gametophyte, plays a crucial role in facilitating fertilization by protecting and transporting male sperm cells to the female pistil. Despite their seemingly simple structure, pollen grains undergo intricate development to produce viable sperm cells capable of fertilizing the egg cell. Factors such as resource limitation and plant aging can disrupt normal pollen development and affect pollen performance.

Effects of maternal preconception high-fat diet on the fertility of dams and on the somatic parameters and reflex ontogeny of their male offspring.

Background: Female consumption of a high-fat diet (HFD) may cause fertility issues and affects offspring development.

Objective: Evaluate the acute maternal preconception intake of a HFD on the fertility and reproduction parameters of breeding females; and on the somatic parameters and reflex ontogeny of male offspring.

Methods: Twenty-four rats were randomized into control (PC; n=12) and high-fat diet group (PHF; n=12) that consumed their respective diets during the 23-day preconception period.

Seroma incidence and risk factors in women undergoing mastectomies as surgical breast cancer treatment.

Introduction: Seroma is the most common early complication following surgical breast cancer treatment. Its development is associated with pain, scar complications, adjuvant therapy delays, the need for outpatient visits, and increased care costs.

Objective: Assess seroma incidence and risk factors in women undergoing mastectomies.

Diffusion tensor metrics, motor and non-motor symptoms in de novo Parkinson's disease.

Introduction: Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurons' degeneration of the substantia nigra, presenting with motor and non-motor symptoms. We hypothesized that altered diffusion metrics are associated with clinical symptoms in de novo PD patients.

Methods: Fractional Anisotropy (FA) and Mean (MD), Axial (AD), and Radial Diffusivity (RD) were assessed in 55 de novo PD patients (58.

A non-targeted metabolomics comparative study on plasma of pfizer and sinopharm COVID-19 vaccinated individuals, assessed by (TIMS-QTOF) mass spectrometry.

Unlabelled: COVID-19 is a highly contagious infectious disease that has posed a global threat, leading to a widespread pandemic characterized by multi-organ complications and failures.

Aims: The present study was conducted to evaluate the impact of Pfizer and Sinopharm vaccines on metabolomic changes and their correlations with immune pathways.

Main Methods: The study used a cross-sectional design and implemented an untargeted metabolomics-based approach.

Identification of human circulating factors following remote ischemic conditioning (RIC): Potential impact on stroke.

Remote ischemic conditioning (RIC) is a procedure consisting of short cycles of ischemia applied in a limb that activates endogenous protection in distant organs, such as the brain. Despite the promising outcomes of RIC, the biochemical factors governing inter-organ communication remain largely unexplored, particularly in humans. A pilot study on 20 healthy humans was performed to identify potential circulating biochemical factors involved in RIC signalling.

Correction: Candida albicans PPG1, a serine/threonine phosphatase, plays a vital role in central carbon metabolisms under filament-inducing conditions: a multi-omics approach.

[This corrects the article DOI: 10.1371/journal.pone.

Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being.

The gut microbiota and its secreted metabolites play a significant role in cardiovascular and musculoskeletal health and diseases. The dysregulation of the intestinal microbiota poses a significant threat to cardiovascular and skeletal muscle well-being. Nonetheless, the precise molecular mechanisms underlying these changes remain unclear.

Fraud-proof methylcellulose-based fish freshness indicator: Reversibility in halochromic sensing of basic volatiles is tailored by ionic strength.

Food from animal sources (e.g., fish) represents the food group most likely to disseminate diseases to humans.

Comparative proteomic analysis of saliva from chewing tobacco users and oral cancer patients reveals shared biomarkers: A case control observational study.

Objective: The aim of this study was to compare the salivary proteomic profile of smokeless tobacco users with that of non-users and oral cancer patients using Liquid Chromatography-Mass Spectrometry/ Mass Spectrometry (LC-MS/MS).

Methods: Saliva samples from 65 participants were collected in three groups: control (25 participants), smokeless tobacco users (25 participants), and oral cancer (15 participants).

Results: The analysis revealed 343 protein groups with significantly altered abundance in the saliva samples (P < 0.

Species Diversity of Anastrepha Fruit Flies (Diptera: Tephritidae) in Environments with Different Levels of Anthropogenic Changes.

Studies on the diversity of Anastrepha species have been conducted mainly in agricultural orchards due to the economic importance of this insect group, consequently, research on fruit flies in undisturbed environments is scarce. Moreover, very few studies have investigated the diversity of fruit flies in urban areas, where fruit flies survive under native or exotic hosts. Thus, to understand the diversity of Anastrepha species in an environment with different anthropization degrees, surveys were carried out in four areas of the "Luiz de Queiroz" campus, in Piracicaba, São Paulo State (Brazil), using Multilure traps with putrescine and ammonium acetate for 12 months.

Proteomic and metabolomic profiling of methicillin resistant versus methicillin sensitive using a simultaneous extraction protocol.

Background: Understanding the biology of methicillin resistant (MRSA) is crucial to unlocking insights for new targets in our fight against this antimicrobial resistant priority pathogen. Although proteomics and metabolomic profiling offer the potential to elucidating such biological markers, reports of methodological approaches for carrying this out in isolates remain limited. We describe the use of a dual-functionality methanol extraction method for the concurrent extraction of protein and metabolites from and report on the comparative analysis of the proteomic and metabolomic profiles of MRSA versus methicillin sensitive (MSSA).