Publications by authors named "So-Woon Han"
Stem Cell Rev Rep
December 2024
Article Synopsis
- Engraftable hematopoietic stem cells (HSC) can be sourced from bone marrow, umbilical cord blood, and peripheral blood, but finding a matched unrelated donor presents a challenge.
- The study focused on enhancing the efficiency of producing patient-specific induced pluripotent stem cell-derived hematopoietic stem cells (iHSC) by using an antioxidant treatment (ginsenoside Rg1) and verifying engraftment in mice models.
- Results showed that iHSC treated with Rg1 had high colony forming efficiency in vitro and successful engraftment in mice conditioned with high doses of busulfan, suggesting a new method for creating HSC that could be used in future transplants and potentially paired with gene-edit
