Publications by authors named "So-Heun Lee"
Background: Numerous studies have explored the role of vitamin D in various cancers; however, its impact on advanced biliary tract cancers (BTC) within a prospective cohort remains to be investigated. This preplanned subgroup analysis of the NIFTY trial evaluated the prognostic implications of serum vitamin D levels in patients with advanced BTC undergoing second-line chemotherapy.
Methods: From the 174 patients in the NIFTY trial, a total of 173 patients (99.
Article Synopsis
- Lenvatinib is a treatment for advanced hepatocellular carcinoma (aHCC), but it can increase the risk of bleeding from esophagogastric varices (EGVs). This study looked into how common EGVs are, what predicts their bleeding, and the complications they cause in patients receiving lenvatinib.
- A total of 535 cirrhotic patients undergoing lenvatinib treatment were examined. The study found that 44% of these patients had EGVs, with a 3% incidence of bleeding over 12 months, mainly occurring in patients identified as being at high risk for EGVs.
- The only notable predictor for EGV bleeding was having high-risk
Background: Unintended secondary changes in the posterior tibial slope (PTS) and tibial torsion angle (TTA) may occur after medial open-wedge high tibial osteotomy (MOWHTO). In surgical procedures using patient-specific instruments (PSIs), it is essential to reproduce the PTS and TTA that were planned in simulations.
Purpose: To analyze the factors causing unintended sagittal and axial alignment changes after MOWHTO.
Article Synopsis
- - The study focuses on the increasing significance of exon 20 insertion mutations (E20ins) in EGFR and HER2 within non-small cell lung cancer (NSCLC) patients, highlighting the growing number of targeted therapies available for these mutations.
- - Between December 2013 and July 2021, researchers identified E20ins in 107 patients, with a notable discordance rate of 53.1% between identification methods (PCR and NGS) for EGFR mutations, indicating the importance of using advanced testing methods like NGS for accurate detection.
- - The results showed that targeted therapies for E20ins significantly outperformed traditional platinum-based treatments, achieving better objective response rates and progression-free survival, underscoring
Background: The transition of human epidermal growth factor receptor 2 (HER2) status after neoadjuvant chemotherapy (NAC) in HER2-low breast cancer has not been thoroughly evaluated. Here, we evaluated the HER2 transition among HER2-zero and HER2-low breast cancer cases post-NAC and its impact on clinical outcomes.
Methods: We included 1288 patients with HER2-low or zero breast cancer who underwent NAC and surgery between 2014 and 2018 and had paired pre- and post-therapeutic HER2 status results.
Purpose: The benefit of adjuvant chemotherapy following curative-intent surgery in pancreatic ductal adenocarcinoma (PDAC) patients who had received neoadjuvant FOLFIRINOX is unclear. This study aimed to assess the survival benefit of adjuvant chemotherapy in this patient population.
Materials And Methods: This retrospective study included 218 patients with localized non-metastatic PDAC who received neoadjuvant FOLFIRINOX and underwent curative-intent surgery (R0 or R1) between January 2017 and December 2020.
Background: Adjuvant chemotherapy is the standard treatment after curative-intent surgery for pancreatic ductal adenocarcinoma (PDAC). The phase-3 ESPAC-4 trial demonstrated significantly improved overall survival (OS) with Gemcitabine plus capecitabine (GemCap) over Gemcitabine (Gem) in Europe. We conducted a retrospective efficacy and safety evaluation of GemCap Gem in an Asian population.
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