Publications by authors named "So Young Jeon"
Unlike other microbothriid monogenean infections in elasmobranchs, limited information is available on the biology and treatment of . As parasitic infection with was found in 21 juvenile blacktip reef sharks () at the Lotteworld aquarium in Seoul, South Korea, we aimed to investigate the anatomical features and treatment protocols for in this study. The parasites were sampled and fixed in 10% neutral-buffered formalin, and examined using light and scanning electron microscopy.
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- Ultra-early diffusion-weighted MRI (DW-MRI) can predict poor neurological outcomes post-cardiac arrest, primarily when performed within 6 hours of achieving spontaneous circulation (ROSC).
- In a study involving 206 patients, high-signal intensity (HSI) on ultra-early DW-MRI was linked to poor outcomes, with specific CPR factors affecting its presence.
- Key findings highlighted that the timing between ROSC and DW-MRI scan significantly influences HSI results, particularly for patients with shorter low-flow times or those presenting with a shockable rhythm.
Article Synopsis
- The study focused on how cerebrospinal fluid (CSF) flow changes relate to neurological outcomes in patients who had an out-of-hospital cardiac arrest (OHCA).
- It included 30 patients, measuring CSF flow with MRI immediately after they regained consciousness and again 72 hours later.
- Results showed that while there was no significant difference in immediate CSF flow direction between groups with good and poor outcomes, at 72 hours, a much higher percentage of poor prognosis patients exhibited a specific CSF flow direction indicating worse neurological status.
Objective: Height has the strongest correlation with esophageal length among the external anthropometric indices. Based on the association between laryngopharyngeal reflux (LPR) and the upper esophageal sphincter, this study aimed to investigate the relationship between height and LPR.
Methods: Retrospective chart analysis of patients who visited an outpatient clinic with symptoms of LPR and underwent a 24-hour hypopharyngeal-esophageal multichannel intraluminal impedance-pH (24-hr HEMII-pH) monitoring.
Background: Patients with radiographic axial spondyloarthritis (r-axSpA) are at increased risk of incident cardiovascular events. Tumor necrosis factor inhibitors (TNFi) have shown a protective effect against incident cardiovacular events. However, the incidence of recurrent cardiovascular events in patients with r-axSpA with a history of cardiovascular events, and the effect of TNFi on recurrent cardiovascular events remain unclear.
View Article and Find Full Text PDFInterleukin-6 (IL-6) was suggested as a potential target for intervention to mitigate brain injury. However, its neuro-protective effect in post-resuscitation care has not been proven. We investigated the time-course of changes in IL-6 and its association with other markers (systemic inflammation and myocardial and neuronal injury), according to the injury severity of the cardiac arrest.
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- TOX is a transcription factor linked to T cell exhaustion during chronic infections, but its role in inflammation, particularly during COVID-19, is not well understood.
- The study found that TOX promotes severe inflammation by binding to the RAGE receptor during SARS-CoV-2 infection, leading to critical lung issues like acute respiratory distress syndrome (ARDS).
- Interventions that block TOX or disable RAGE showed potential in reducing harmful effects, suggesting that targeting the TOX-RAGE pathway could be a promising strategy for treating severe pulmonary infections.
We investigated the agreement between the jugular bulb (JB) and cerebrospinal fluid (CSF) lactate levels. The study was conducted from July 2021 to June 2023 as a prospective observational cohort study at a single center. The right jugular vein was accessed, and the placement of JB catheter tip was confirmed using lateral cervical spine X-ray.
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- - The study investigates how changes in cerebrospinal fluid (CSF) dynamics affect brain function in patients with hypoxic-ischemic brain injury (HIBI) after cardiac arrest (CA), specifically focusing on the CSF partial pressure of carbon dioxide (PcsfCO) as a potential marker for neurological outcomes.
- - Among 67 CA survivors analyzed, 58.2% exhibited poor neurological outcomes, with significant differences in PcsfCO levels identified; notably, lower PcsfCO on Day 1 had strong predictive power for poor outcomes, suggesting its diagnostic relevance.
- - The findings highlight PcsfCO as a valuable indicator for assessing the severity of HIBI and CSF dynamics during targeted temperature
Administration of sedatives for post-resuscitation care can complicate the determination of the optimal timing to avoid inappropriate, pessimistic prognostications. This prospective study aimed to investigate the distribution and elimination kinetics of midazolam (MDZ) and its metabolites, and their association with awakening time. The concentrations of MDZ and its seven metabolites were measured immediately and at 4, 8, 12, and 24 h after the discontinuation of MDZ infusion, using liquid chromatography-tandem mass spectrometry.
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- The study investigated how the blood-brain barrier (BBB) permeability and intracranial pressure (ICP) change in the first 24 hours after spontaneous circulation returns following cardiac arrest.
- It involved measuring BBB permeability using the albumin quotient (Qa) and monitoring ICP every 2 hours in 32 patients, while also assessing the severity of cardiac arrest injuries with Pittsburgh Cardiac Arrest Category (PCAC) scores.
- Results indicated that BBB permeability increased significantly after 18 hours, especially in patients with more severe injuries (PCAC 3 and 4), while ICP remained stable throughout the 24 hours.
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- Effective triage of febrile patients is essential in emergency departments, especially during overcrowding and pandemics, and requires a reliable tool for prioritizing care and resources.
- The study developed a modified version of the qSOFA score called ASqSOFA, which incorporates factors like age, sex, oxygen saturation, and lactate levels, showing accuracy in predicting in-hospital mortality and ICU admissions.
- ASqSOFA outperforms other existing triage scales and offers a simple scoring system, making it useful for emergency settings and potential prehospital applications.
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- The study aimed to explore how cerebral metabolism and cerebrospinal fluid (CSF) lactate levels differ in patients who experienced out-of-hospital cardiac arrest (OHCA) after they regained spontaneous circulation (ROSC).
- Researchers measured CSF lactate and pyruvate every 2 hours for 24 hours post-ROSC and assessed mitochondrial dysfunction and ischemia in the brain.
- Findings showed that the presence of cerebral dysfunction and ischemia decreased over time, especially in patients with moderate severity; CSF lactate levels were more predictive of poor neurological outcomes in this group compared to others, highlighting the importance of severity in evaluating brain health after OHCA.
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- Adoptive cell therapy using CAR technology is a cutting-edge method in cancer treatment, showing strong results for blood cancers but facing challenges with solid tumors due to factors like the tumor microenvironment and lack of specific antigens.
- Recent improvements in CAR-T cell design, like co-stimulatory domains and armored variants, have provided better outcomes, yet challenges remain.
- Alternative immune cells, such as CAR-NK and CAR-M cells, are being explored for their unique advantages, including lower toxicity and better infiltration of solid tumors, with ongoing clinical trials assessing their effectiveness and safety.
Article Synopsis
- The study aims to understand how midazolam, a medication, distributes in serum and cerebrospinal fluid (CSF) to improve neurological prognosis timing in patients undergoing targeted temperature management after cardiac arrest.
- Conducted between May 2020 and April 2022, the research measured midazolam and albumin levels at different time intervals after cardiac arrest, comparing results between good and poor neurological outcome groups.
- Findings revealed that while midazolam and albumin peaked in CSF 24 hours post-arrest, poor outcome patients had significantly higher CSF/serum ratios of both substances, indicating possible blood-brain barrier disruption.
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- The study assessed the effectiveness of the Korean Modified Early Warning Score (KMEWS) as a triage tool for screening infections in emergency department patients.
- Researchers analyzed data from patients over 18 who showed signs of infection from January 2018 to December 2019, calculating KMEWS by combining the Modified Early Warning Score (MEWS) and the Korean Triage and Acuity Scale (KTAS).
- Results indicated that KMEWS was particularly good at predicting septic shock, with high performance metrics compared to other scales, suggesting it could improve triage processes for infected patients in emergency settings.
Article Synopsis
- The study investigates the relationship between reactogenicity (adverse effects) and immunogenicity (immune response) of the ChAdOx1 COVID-19 vaccine among South Korean healthcare workers.
- Participants received two doses of the vaccine, and their immune response was measured alongside reported side effects after each dose.
- Results showed a significant drop in adverse events after the second dose and a notable increase in immune response for those who experienced pain after the first dose.
Purpose: To evaluate the differences in diagnostic rates according to the age and sex of patients with suspected laryngopharyngeal reflux (LPR) symptoms and completed the 24-hour hypopharyngeal-esophageal multichannel intraluminal impedance-pH (24h-HEMII-pH) monitoring.
Methods: Patients with LPR symptoms underwent the 24h-HEMII-pH monitoring. We compared the diagnostic rates of LPR in patients with LPR symptoms according to age and sex.
Although idiopathic sudden sensorineural hearing loss (ISSNHL) is uncommon, recurrent ISSNHL is even rarer. The knowledge about factors associated with patient recovery from recurrent episodes is needed to counsel and treat the patients. Medical records of patients admitted for high dose oral steroid therapy for recurrent ISSNHL between January 2009 and December 2021 were reviewed.
View Article and Find Full Text PDFPurpose: To investigate the longitudinal trend of symptomatic distal radioulnar joint (DRUJ) instability after plate fixation for distal radius fractures (DRFs), determine which factors are associated with persistent symptomatic DRUJ instability, and evaluate the postoperative outcomes of arthroscopic foveal repair of the triangular fibrocartilage complex (TFCC) in patients with persistent symptomatic DRUJ instability after plate fixation for DRF.
Methods: All consecutive patients who underwent plate fixation for DRF between January 2014 and December 2017 and were followed up for a minimum of 1 year were included in this retrospective study. DRUJ instability was evaluated by subjective ulnar wrist pain and physical examination that included foveal sign and ballottement testing every 2 months after surgery.
Purpose: To verify the role of lactate dehydrogenase to albumin (LDH/ALB) ratio as an independent prognostic factor for mortality due to the lower respiratory tract infection (LRTI) in the emergency department (ED).
Methods: We reviewed the electronic medical records of patients who were admitted to the ED for the management of LRTI between January 2018 and December 2020. Initial vital signs, laboratory data, and patient severity scores in the ED were collected.
This study was performed to verify whether lactate dehydrogenase to albumin (LDH/ALB) ratio could be used as an independent prognostic factor in patients with severe infection requiring intensive care.We reviewed electronic medical records of patients hospitalized to the intensive care unit via the emergency department with a diagnosis of infection between January 2014 and December 2019. From the collected data, ALB-based ratios (LDH/ALB, blood urea nitrogen to albumin, C-reactive protein to albumin, and lactate to albumin ratios) and some severity scores (modified early warning score, mortality in emergency department sepsis score [MEDS], and Acute Physiology And Chronic Health Evaluation II [APACHE II] score) were calculated.
View Article and Find Full Text PDFObjectives: To assess the validity and reliability of the Korean version of the reflux symptom score (K-RSS).
Materials And Methods: The English version of the RSS was translated into Korean and completed by 77 people (44 and 33 people in the patient group and control group, respectively). They completed the K-RSS (K-RSS-1) and reflux symptom index (RSI) questionnaires and answered questions about age, sex, underlying disease, smoking history, and alcohol and coffee consumption.
Background: Postpartum hemorrhage (PPH) constitutes a major risk for maternal mortality and morbidity. Unfortunately, the severity of PPH can be underestimated because it is difficult to accurately measure blood loss by visual estimation. The delta neutrophil index (DNI), which reflects circulating immature granulocytes, is automatically calculated in hematological analyzers.
View Article and Find Full Text PDFBackground: Aconitine is well-known for its potential analgesic, anti-inflammatory, and circulation promoting effects and has been widely used as a folk medicine in South Korea. Owing to its extremely toxic nature and relatively low safety margin, intoxication is sometimes fatal. The toxic compound mainly affects the central nervous system, heart, and muscle, resulting in cardiovascular complications.
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