Publications by authors named "So Young Cho"
Article Synopsis
- * This study introduced a new method using a respirometer to measure oxygen consumption in ICR mice exposed to various concentrations of benzene, toluene, and xylene, revealing significant decreases in respiration rates at high concentrations of benzene and toluene.
- * The method was validated in a model of pulmonary fibrosis, showing a strong link between weight loss and decreased oxygen consumption, suggesting oxygen consumption might serve as a reliable endpoint in inhalation toxicity assessments without needing to sacrifice animals.
Article Synopsis
- The skin serves as a protective barrier against external irritants, and Pilea mongolica (P. mongolica) is a traditional Chinese herb that may help reduce inflammation, despite limited research on its effects.
- This study investigated the anti-inflammatory properties of the methanol extract of P. mongolica (MEPM) on LPS-stimulated human skin cells, showing that it significantly lowered inflammatory markers without being toxic to the cells.
- The study identified geraniin, an active compound in MEPM, as a key player in these anti-inflammatory effects, suggesting that MEPM and geraniin could be valuable for developing natural cosmetic products.
Article Synopsis
- Particulate matter (PM) pollution, linked to various health issues, has not been thoroughly studied in relation to the development of schizophrenia.
- This study exposed preadolescent mice to PM and examined the impact on schizophrenia-like behaviors, finding that PM exposure worsened symptoms like social deficits and cognitive impairments in adulthood.
- The research also revealed that PM exposure reduced levels of brain-derived neurotrophic factor (BDNF) and affected related signaling pathways, suggesting a biological mechanism behind the exacerbation of schizophrenia symptoms.
Article Synopsis
- * A study tested the effects of a novel herbal complex called LK5, which has anti-inflammatory properties, on HaCaT cells and in a mouse model of AD.
- * Results showed that LK5 reduced expression of inflammatory cytokines, improved clinical symptoms in mice, and inhibited itch, indicating its potential to modulate the immune response and alleviate AD symptoms by targeting the JAK-STAT pathway.
The Anti-Atopic Dermatitis Effects of Essential Oil Are Involved in the Inhibition of the NLRP3 Inflammasome in DNCB-Challenged Atopic Dermatitis BALB/c Mice.
Int J Mol Sci
April 2023
Article Synopsis
- The NLRP3 inflammasome, which is promoted by certain agents, plays a key role in increasing IL-1β levels, contributing to the worsening of atopic dermatitis (AD) symptoms.
- Despite its critical role, there are currently no drugs specifically targeting the NLRP3 inflammasome for AD patients.
- Research showed that MAEO can inhibit NLRP3 inflammasome activation and reduce AD symptoms in laboratory tests and animal models, suggesting its potential as a treatment for AD.
Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3β-NF-κB signalling pathway in MK-801-treated mice.
J Ethnopharmacol
October 2023
Article Synopsis
- Cynanchum paniculatum has a history of use in East Asia for its pain-relieving and antiviral properties, and traditional texts indicate potential benefits for treating psychotic symptoms like hallucinations and delusions.
- The study investigated the effects of C. paniculatum and its main compound, paeonol, on mice with schizophrenia-like behaviors induced by MK-801, finding that paeonol may help alleviate symptoms.
- Results showed that both C. paniculatum extract and paeonol improved sensorimotor gating and cognitive deficits in the mice, suggesting paeonol could be a promising treatment for schizophrenia-related issues.
Purpose: The aim of this study was to analyze several technical and clinical factors associated with the successful management of postoperative leakage by percutaneous Foley catheter placement.
Materials And Methods: Thirty-two patients were included in this retrospective study. Postoperative gastrointestinal leakage was diagnosed by computed tomography (CT) and the patients underwent percutaneous Foley catheter placement into the leakage site through Jackson-Pratt tubes or imaging-guided methods.
Blockade of lipid accumulation by silibinin in adipocytes and zebrafish.
Chem Biol Interact
February 2015
Silibinin is a compound present mainly in milk thistle. In this study, we investigated the mechanism by which silibinin suppresses adipogenesis of 3T3-L1 cells, and evaluated the anti-adipogenic effect of silibinin in zebrafish. Silibinin reduced lipid accumulation by downregulating adipogenic factors, such as, peroxisome proliferator-activated receptor γ (PPARγ), CCAAT-enhancer binding protein α (C/EBPα), and fatty acid-binding protein 4 (FABP4).
View Article and Find Full Text PDFTannases are important enzymes in the antioxidant potential of tea leaves. In this study, we evaluated the effect of two tannases (T1 and T2) on biotransformation of tea polyphenols and antioxidative activities from catechins in green tea extract (GTE). The T1 tannase-catalyzed reaction was inhibited by the addition of >2.
View Article and Find Full Text PDFAntioxidant Effect and Functional Properties of Hydrolysates Derived from Egg-White Protein.
Korean J Food Sci Anim Resour
January 2016
This study utilized commercially available proteolytic enzymes to prepare egg-white protein hydrolysates (EPHs) with different degrees of hydrolysis. The antioxidant effect and functionalities of the resultant products were then investigated. Treatment with Neutrase yielded the most α-amino groups (6.
View Article and Find Full Text PDFPromyelocytic leukaemia (PML) protein, the product of the pml gene, is heterogeneously expressed in various normal and neoplastic tissues, and the fusion of the pml gene with retinoic acid receptor-alpha is believed to be a central mechanism in acute PML tumourigenesis. As PML is important for controlling major cellular processes, such as growth and differentiation, it is believed that it plays an important role during human gestation. The human placenta is a critical organ for the maintenance of gestation, but the expression pattern and functional significance of PML in the placenta have not been documented.
View Article and Find Full Text PDFPeripheral primitive neuroectodermal tumor (PNET) and Ewing's sarcoma (ES) constitute a unique group of small round cell tumors in childhood and young adults that are characterized by the same chromosomal translocation t(11;22)(q24;q12). Recently, the expression of neurotrophin receptors has been found in various human tumors including PNET/ES, but the functional significance of these receptor expressions has not been documented in PNET/ES. In the present study, we investigated the biologic effects of trkA neurotrophin receptor activation by nerve growth factor (NGF) in a newly established Askin tumor cell line, JK-GMS, which constitutively expresses a high level of trkA.
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