Mitochondrial SIRT3 as a protective factor against cyclosporine A-induced nephrotoxicity.

Sirtuin3 (SIRT3), a mitochondrial deacetylase, has been shown to be involved in various kidney diseases. In this study, we aimed to clarify the role of SIRT3 in cyclosporine-induced nephrotoxicity and the associated mitochondrial dysfunction. Madin-Darby canine kidney (MDCK) cells were transfected with Flag-tagged SIRT3 for SIRT3 overexpression or SIRT3 siRNA for the inhibition of SIRT3.

Effectiveness of remote monitoring and feedback on objective compliance with a mandibular advancement device for treatment of obstructive sleep apnea.

Compliance with a mandibular advancement device is important for the optimal treatment of obstructive sleep apnea. Recent advances in information and communication technology-based monitoring and intervention for chronic diseases have enabled continuous monitoring and personalized management. Self-evaluation and self-regulation through objective monitoring and feedback may improve compliance.

Registration of digital dental models and cone-beam computed tomography images using 3-dimensional planning software: Comparison of the accuracy according to scanning methods and software.

Introduction: The registration of cone-beam computed tomography (CBCT) images and digital dental models is required for the design and manufacturing of dental devices such as implant guides and surgical wafers. This study aims to register intraoral scan (IS) models and cast scan (CS) models onto CBCT images using 3-dimensional (3D) planning software and evaluate the registration accuracy according to scanning methods and 3D planning software.

Methods: The CBCT image of an artificial skull model with reference markers was taken.

Evaluation of the adaptation of complete denture metal bases fabricated with dental CAD-CAM systems: An in vitro study.

Statement Of Problem: Conventional fabrication of complete denture metal bases is being replaced by the computer-aided design and computer-aided manufacturing (CAD-CAM) systems. However, a comparative analysis of subtractive and additive CAD-CAM manufacturing techniques is lacking.

Purpose: The purpose of this in vitro study was to compare the adaptation of complete denture metal bases fabricated by milling (subtractive manufacturing) and stereolithography apparatus (SLA) and digital light processing (DLP) (additive manufacturing).

Evaluation of the accuracy (trueness and precision) of a maxillary trial denture according to the layer thickness: An in vitro study.

Statement Of Problem: Layer thickness in additive manufacturing has stair-step effects that greatly affect the accuracy of the definitive prosthesis. Although the layer thickness can be set, insufficient data comparing and analyzing the accuracy of the fabricated prosthesis after adjusting the layer thickness are available.

Purpose: The purpose of this in vitro study was to evaluate and compare the accuracy of trial dentures fabricated with different layer thicknesses by using stereolithography (SLA) apparatus.

The role of nuclear factor erythroid-2-related factor 2 expression in radiocontrast-induced nephropathy.

Radiocontrast-induced nephropathy (CIN) is the third most common cause of acute renal failure. The pathophysiology of CIN is related to tubular injury caused by oxidative stress, and nuclear factor erythroid-2-related factor 2 (Nrf2) is critical in coordinating intracellular antioxidative processes. We thus investigated the role of Nrf2 in CIN.

Resveratrol Ameliorates Contrast Induced Nephropathy Through the Activation of SIRT1-PGC-1α-Foxo1 Signaling in Mice.

Background/aims: SIRT1 activation promotes the resistance of renal tubular cells to oxidative stress, and resveratrol is known as a SIRT1 activator.

Methods: Resveratrol was injected intraperitoneally with iohexol for 24 hours. NRK-52E cells were pretreated with resveratrol for 24 hours and then exposed to iohexol for 3 hours.

Evaluation of the marginal and internal gaps of three different dental prostheses: comparison of the silicone replica technique and three-dimensional superimposition analysis.

Purpose: The purposes of this study were to evaluate the marginal and internal gaps, and the potential clinical applications of three different methods of dental prostheses fabrication, and to compare the prostheses prepared using the silicone replica technique (SRT) and those prepared using the three-dimensional superimposition analysis (3DSA).

Materials And Methods: Five Pekkton, lithium disilicate, and zirconia crowns were each manufactured and tested using both the SRT and the two-dimensional section of the 3DSA. The data were analyzed with the nonparametric version of a two-way analysis of variance using rank-transformed values and the Tukey's post-hoc test (α = .

Three-dimensional analysis of marginal and internal fit of copings fabricated with polyetherketoneketone (PEKK) and zirconia.

Purpose: The purpose of this in vitro study was to compare and analyze the three-dimensional marginal and internal fit of PEKK and zirconia copings.

Methods: Two acrylic models of the right maxillary canine, first molar were fabricated as master dies and duplicated by one-step dual viscosity impressions. Five stone replicas from each model were digitized with a blue-light scanner and copings were machined from Pekkton and Zirconia blanks.

In vitro assessment of the marginal and internal fits of interim implant restorations fabricated with different methods.

Statement Of Problem: The fit of an interim implant restoration (IIR) is important for the effective treatment of patients with partial edentulism. However, no clinical trials have evaluated the marginal and internal fittings achieved with various fabrication methods.

Purpose: The purpose of this in vitro study was to evaluate and compare the marginal and internal discrepancies in IIRs produced with 3 different methods.

Translucency of zirconia-based pressable ceramics with different core and veneer thicknesses.

Statement Of Problem: Little information is available on the translucency of zirconia-based pressable ceramic restorations with a pressed ceramic veneer and zirconia core in various thickness combinations.

Purpose: The purpose of this in vitro study was to assess the translucency of 3 types of zirconia-based pressable ceramics for different core-veneer thickness combinations.

Material And Methods: A bilayered ceramic specimen was prepared with a pressable ceramic (IPS e.

Radiocontrast-induced nephropathy is attenuated by autophagy through regulation of apoptosis and inflammation.

Radiocontrast-induced nephropathy (RCN) is the third most common cause of acute renal failure among inpatients. Although the number of patients undergoing exams using radiocontrast is increasing, little progress has been made for RCN treatment. The pathophysiology of RCN is known as tubular injury due to oxidative stress.