Assessing unknown potential-quality and limitations of different large language models in the field of otorhinolaryngology.

Background: Large Language Models (LLMs) might offer a solution for the lack of trained health personnel, particularly in low- and middle-income countries. However, their strengths and weaknesses remain unclear.

Aims/objectives: Here we benchmark different LLMs (Bard 2023.

The effectiveness of voluntary modifications of gait pattern to reduce the knee adduction moment.

It has been suggested to use gait modifications in the retraining of patients with knee osteoarthritis (OA), in order to reduce the external knee adduction moment (KAdM). This study focused on the effect of walking speed, foot position and trunk sway, and on the 3D knee moments. Gait analyses of fourteen healthy volunteers were performed in a gait laboratory.

Specimen specific, 3D modeling of the elbow--prediction of strain in the medial collateral ligament.

In this project 3D interactive models of twelve cadaver elbows are developed using the author's kinematic simulation software. The effective flexion-extension axes for each specimen's model are iteratively defined based upon congruent joint motion and individual limits in range-of-motion. Origins and insertions of both parts of the medial collateral ligament are digitized following careful dissection of each specimen.

Calculation of the redox potential of the protein azurin and some mutants.

Azurin from Pseudomonas aeruginosa is a small 128-residue, copper-containing protein. Its redox potential can be modified by mutating the protein. Free-energy calculations based on classical molecular-dynamics simulations of the protein and from mutants in aqueous solution at different pH values were used to compute relative redox potentials.

Phase II trial of cisplatin and gemcitabine in patients with advanced gastric cancer.

Background: This phase II study was performed to determine the efficacy and toxicity of cisplatin and gemcitabine in patients with advanced gastric cancer.

Patients And Methods: Forty chemo-naïve patients with measurable locoregionally advanced or metastatic gastric cancer were included; the median patient age was 53 years (range 35-71). Cisplatin was administered at a dose of 50 mg/m2, given in 1 h intravenously (i.

Decontamination of broilers with hydrogen peroxide stabilised with glycerol during processing.

Experiments were conducted to assess the effects of different concentrations of hydrogen peroxide stabilised by glycerol solution in potable water on the bacteriological and organoleptic quality of freshly slaughtered broiler carcasses. Skin-pH and colour were measured 3.5 and 24 h after treatment and compared to untreated carcasses.

Electronic structures and nonlinear optical properties of trinuclear transition metal clusters M-(mu-S)-M' (M = Mo, W; M' = Cu, Ag, Au).

A series of trinuclear metal clusters MS4(M'PPh3)2(M'PPh3) (M = Mo, W; M' = Cu, Ag, Au) have been studied using the density functional theory (DFT) method. The static polarizabilities and hyperpolarizabilities of the model clusters have been calculated using the finite-field (F-F) method. The model clusters, divided into two groups, are alike in the structure of two fragments of rhombic units M-(mu-S)2-M' (M = Mo, W; M' = Cu, Ag, Au), perpendicular to each other, which are joined by sharing the bridge metal M.

Signal transduction in the photoactive yellow protein. I. Photon absorption and the isomerization of the chromophore.

Molecular dynamics simulation techniques together with time-dependent density functional theory calculations have been used to investigate the effect of photon absorption by a 4-hydroxy-cinnamic acid chromophore on the structural properties of the photoactive yellow protein (PYP) from Ectothiorodospira halophila. The calculations suggest that the protein not only modifies the absorption spectrum of the chromophore but also regulates the subsequent isomerization of the chromophore by stabilizing the isomerization transition state. Although signaling from PYP is thought to involve partial unfolding of the protein, the mechanical effects accompanying isomerization do not appear to directly destabilize the protein.

Effect of fermented feed on shedding of Enterobacteriaceae by fattening pigs.

Epidemiological studies showed that the use of fermented feed could significantly reduce Salmonella prevalence in pigs compared to the use of normal feed. Experimental challenge experiments with Salmonella have however never been conducted to reveal the efficacy of fermented feed in reducing Salmonella shedding and/or reducing the number of Salmonella-positive pigs. A longitudinal study was conducted to measure the effect of fermented feed, in particular of its components lactic acid and Lactobacillus plantarum, on gastrointestinal bacterial ecology (Salmonella, Enterobacteriaceae, lactobacilli, volatile fatty acids (VFAs), pH).

Ultranonlocality in time-dependent current-density-functional theory: application to conjugated polymers.

We solve the long-standing problem of the large overestimation of the static polarizability of conjugated polymers obtained using the local density approximation within density-functional theory. The local approximation is unable to describe the highly nonlocal exchange and correlation (xc) effects found in these quasi-one-dimensional systems. Time-dependent current-density-functional theory enables a local current description of ultranonlocal xc effects using the Vignale-Kohn functional [G.

[From veterinarian to quality control manager. What is going to change in the Netherlands for the practicing large animal veterinarian under influence of the White Paper about food safety?].

The work of farm animal practitioners will change in the coming years as a result of the White Paper on food safety. Both government and the Royal Veterinary Association of the Netherlands are working on an accreditation system for veterinarians. The veterinary practitioner is a link in the chain to achieve safe products.

Salmonella in slaughter pigs: prevalence, serotypes and critical control points during slaughter in two slaughterhouses.

The purpose of this study was to show the distribution of Salmonella in slaughtered pigs and the environment of the slaughterhouse. 1,114 samples of slaughtered pigs (six different samples for Salmonella isolation and one serum sample for ELISA on antibodies per pig) and 477 samples of the slaughterhouse environment were collected in two slaughterhouses on two sampling days per slaughterhouse. Salmonella was isolated from one or more samples of 47% of the pigs.

Salmonella in slaughter pigs: the effect of logistic slaughter procedures of pigs on the prevalence of Salmonella in pork.

A substantial part of the finishing pigs in the Netherlands is infected with Salmonella. Infection of pigs with Salmonella can occur already on the farm. Pigs can also get infected or contaminated during transport, lairage or slaughter.

Epidemiological investigations into the sources of Salmonella contamination of pork.

This study was conducted to elucidate which phases of the pork production chain contribute to the Salmonella contamination on pork after slaughter. During 7 sampling days, samples were collected of randomly selected slaughter pigs and of pigs from selected Salmonella-infected and Salmonella-free herds, trucks, lairages, and slaughterlines, in two slaughterhouses. Salmonella genotypes, present on pork after slaughter, were compared with Salmonella types, present on the farm, in the truck, in the lairage, on slaughter equipment, and in pigs from other herds.

Effect of fermented feed on the microbial population of the gastrointestinal tracts of pigs.

An in vivo experiment was performed with pigs to study the inhibitory effect of fermented feed on the bacterial population of the gastrointestinal tract. Results demonstrated a significant positive correlation between pH and lactobacilli in the stomach contents of pigs in dry feed as well as in the stomach contents of pigs fed fermented feed. Furthermore, a significant positive correlation between the pH and the numbers of bacteria in the family Enterobacteriaceae in the contents of the stomach of pigs fed dry feed was found.

Monitoring of transmission of Salmonella enterica serovars in pigs using bacteriological and serological detection methods.

The standard method to detect Salmonella positive pigs is bacteriological examination of the faeces, but in recent years the use of Salmonella-ELISA's have become available to screen pigs for serological evidence of infection. This study was conducted to monitor the transmission of five different Salmonella enterica serovars (S. Typhimurium, S.

Human health hazards associated with the administration of antimicrobials to slaughter animals. Part I. An assessment of the risks of residues of tetracyclines in pork.

This article describes the assessment of consumer risks of residues of tetracyclines in slaughter pigs in the Netherlands. The assessed risks were toxic and allergic reactions, and the disturbance of the consumers' intestinal flora. Toxic and allergic reactions in humans and animals have only been observed at therapeutic doses, affecting between an estimated 1 in 5,000 and one 1 in 140,000 individuals exposed.

Human health hazards associated with the administration of antimicrobials to slaughter animals. Part II. An assessment of the risks of resistant bacteria in pigs and pork.

Risks for the consumer regarding the acquisition of resistant bacteria and/or resistance genes via the consumption of pork are discussed. In general, Salmonella spp. and Escherichia coli that originate from animals do not easily transfer their resistance genes to the resident intestinal flora of humans.

Salmonella in the lairage of pig slaughterhouses.

The purpose of this study was to determine if lairages of pig slaughterhouses can act as a source of contamination of slaughtered pigs with Salmonella. The prevalence and variety of serotypes of Salmonella in the lairages of two pig slaughterhouses were determined, and the efficacy of the usual cleaning and disinfection on the presence of Salmonella was estimated. Lairages of two pig slaughterhouses were sampled three times when pigs were present.

[A possible approach to improve present meat inspection].

The final decision in the meat inspection mainly depends on the results of the examinations before, during, or directly after the slaughter of animals in the slaughterhouse. The present threats to public health cannot be adequately judged on that place and under these circumstances. A new approach of the meat inspection methods is only possible with the cooperation of the other EU member states and the people who are involved in the meat inspection.

Study on causes and prevention of electrostatic charge build-up during extracorporeal circulation.

For many years it has been known that roller pumps interfere regularly with the electrocardiogram (ECG) signal. This electrical activity is also considered responsible for the electrostatic charge build-up in some oxygenators with a plastic heat exchanger. During use of such an oxygenator, an electrical shock can be felt when touching the device.

Impact on human health of Salmonella spp. on pork in The Netherlands and the anticipated effects of some currently proposed control strategies.

The impact on human health of Salmonella spp. on pork in The Netherlands is described. Subsequently, the effects of some currently proposed control strategies in the Dutch pork production chain are evaluated and quantified with the aid of a simple mathematical model.

Salmonella spp. on pork at cutting plants and at the retail level and the influence of particular risk factors.

This article describes the contamination of pork with Salmonella spp. in cutting plants and butchers' shops in The Netherlands and quantifies the influence of several risk factors. When contaminated carcasses are being processed, the main risk factors regarding cross contamination are inapt cleaning and disinfection (OR 12.

Identification and quantification of risk factors regarding Salmonella spp. on pork carcasses.

The main elements of a descriptive epidemiological model for Salmonella spp. in Dutch pig slaughterlines, and the subsequent quantification of risk factors regarding the contamination of carcasses, are described. There is a strong correlation between the number of live animals that carry Salmonella spp.

Extension of a predictive substrate model for human cytochrome P4502D6.

1. Metoprolol, indoramine, codeine, tamoxifen and prodipine, compounds which are clinically used, and MDMA (ecstasy) were fitted in a small molecule model for substrates of human cytochrome P4502D6. 2.