[Secondary malignancies in late periods after chemoradiotherapy for lymphogranulomatosis in children].

The incidence of secondary malignancies (SM) was studied in a population of 219 patients in late periods (3-29 years) after childhood and adolescence chemoradiotherapy for Hodgkin's lymphoma (HL). SMs were found in 15 (6.8%) patients.

[Transnasosphenoidal microsurgery of hypophyseal adenomas].

The results of surgical treatment of 550 patients through a transnasosphenoidal approach are analysed. The results of management of endosellar and endoextrasellar adenomas are discussed. Various groups of patients are set apart according to the hormonal activity of the tumor.

[Dopaminergic regulation of the hypothalamo-hypophyseal system in patients with hypophyseal adenomas].

A study was made of the state of the hypothalamohypophyseal system in patients with different types of chromophobe adenoma. Altogether 62 patients were examined using metoclopramide and Parlodel tests (38 patients were with somatotropinoma, 13--with prolactinoma, 11--with somatotropinoma with hyperprolactinemia). The time course of STH, PRL and TSH secretion in the blood was investigated.

[Effectiveness of lysenyl-forte treatment in acromegaly and hyperprolactinemia syndrome].

Lysenyl-forte, a derivative of polysynthetic ergot alkaloids, producing a dopaminergic and antiserotoninergic action was employed to treat acromegaly and prolactin hypersecretion in 11 and 71 patients, respectively. Clinical effect was established basing on a complex of clinical, x-ray, neuro-ophthalmologic and hormonal evidence. Acromegaly treatment proved efficient: 7 patients (63%) showed partial relief of clinical signs, reduced STH blood level.

[Endocrine disorders in "empty" sella turcica].

The results of endocrine examination of 37 patients with an "empty" sella turcica (22 with primary and 15 with secondary) are discussed. The diagnosis in all cases was verified by the findings of pneumocisternotomography and computer-aided tomography. The trophic function of the hypophysis was mainly studied.

[Proton therapy of pituitary adenomas].

The authors present the results of proton therapy in 59 patients with different hypophyseal adenomas. The period of observation lasted from 6 mos. to 5 yrs.

[Diagnosis of the functional activity of pituitary adenomas accompanied by hyperprolactinemia].

Comprehensive examination of 24 patients suffering from adenoma of the hypophysis revealed no correlation between the characteristics of computer tomography (the size and density of the tumor, etc) and the level of blood prolactin. Hyperprolactinemia may be encountered both in hormonal active (prolactin secreting) and in hormonal inactive adenoma of the hypophysis.

[Radioimmunoassay in the evaluation of the hormonal activity of pituitary adenomas].

Direct correlation was found between the results of a radioimmunoassay, electron microscopy and immunohistochemistry in cases of STH-secreting and hormonally inactive hypophyseal adenomas. In hyperprolactinemia and a simultaneous increase in the levels of 2 or more hormones the results of the radioimmunoassay coincided with those of electron microscopy and immunohistochemistry in 50-70% of the cases.

[Immunomorphological and ultrastructural characteristics of hypophyseal adenomas in prolactinemia patients].

It was shown by means of electron microscopy and immunohistochemical study that in 11 of 15 patients with high preoperative prolactinemia the tumor consisted mainly of prolactin-containing cells. Small groups of them occurred in the tumors of 2 patients, whereas in 2 other cases prolactin was not detected in the tumor cells by immunohistochemical method. Electron microscopy demonstrated hypophyseal oncocytomas in these 2 cases.

[Functional morphology of pituitary adenoma in acromegaly].

Twenty-one pituitary adenomas removed from patients with acromegaly were studied electron microscopically. In 9 cases the tumors underwent immunohistochemical analysis by Coons' indirect immunofluorescent technique. Before the operation, all the patients were found by radioimmunoassay to have concentrations of pituitary hormones in the blood serum.

[Status of blood coagulation and various background endocrine indices in patients with basal meningiomas during pre- and postoperative periods].

The condition of blood coagulation activity and the indices of the endocrine background were studied in patients with tumors of prevalently basal localization which caused a direct effect on the central regulating centers. Thirty patients with basal and medially located meningiomas were examined in the pre- and postoperative periods. Before the operation most patients had clinical signs of endocrine-metabolic disorders, often in the presence of an increased content of ACTH and cortisol in the blood.