Publications by authors named "Snigdha Mandal"
Article Synopsis
- Tuberculosis (TB) remains a major global health issue, causing an estimated 1.4 million deaths in 2019, highlighting the need for new treatment options due to existing drug resistance and side effects.
- This study focuses on the development of oxindole-based hybrids as potential InhA inhibitors to combat Mycobacterium tuberculosis, involving both anti-mycobacterial activity evaluations and molecular docking studies to understand drug interactions.
- Among the synthesized compounds, 8b demonstrated strong anti-mycobacterial activity and a favorable safety profile, showing promise as a new treatment and adhering to established drug-likeness criteria.
An aerobic microbial fuel cell (MFC) was designed to produce bio-electricity using cow manure-pretreated slurry (CM) and sewage sludge (SS). A comparative study of parametric effects on power generation for various parameters like feed ratio of wastes, pH of anode media, and electrode depth was conducted. This experiment aimed to identify the most important system parameters and optimize them to develop a suitable controller for a stable output.
View Article and Find Full Text PDFObjectives: This investigation was aimed at designing an effective mucoadhesive microemulsion system to accomplish higher brain uptake of curcumin through intranasal route.
Materials And Methods: Mucoadhesive microemulsion of curcumin (MMEC) was developed using screened oil, surfactant, and co-surfactant by Box-Behnken design and was evaluated for mucoadhesion, stability, and naso-ciliotoxicity study. Comparative brain uptake of curcumin after nasal administration of MMEC and polycarbophil curcumin gel and intravenous administration of plain curcumin solution was studied by performing bio-distribution study in Swiss albino rats.
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promising neuroprotection action, but it suffers from high first pass metabolism and limited ability to cross blood brain barrier. Severe gastric toxicity following oral administration further limits its utility. Hence, the aim of this study was to investigate whether ibuprofen loaded mucoadhesive microemulsion (MMEI) could enhance the brain uptake and could also protect the dopaminergic neurons from MPTP-mediated neural inflammation.
View Article and Find Full Text PDFBackground: The present study is to investigate the neuroprotective effect of ibuprofen by intranasal administration of mucoadhesive microemulsion (MMEI) against inflammation-mediated by dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease (PD).
Methods: Ibuprofen-loaded polycarbophil-based MMEI was developed by using response surface methodology (RSM). Ibuprofen with dose of 2.