Duration of fermentation affects microbiome composition and biological activity of an Indian traditional formulation - Panchagavya.

Objective: This study aimed at investigating whether the duration of fermenting Panchagavya (PG) preparation in copper vessel affects its biological activity and microbiome composition.

Materials And Methods: Prophylactic potential of PG against bacterial infection was assessed through an in vivo assay employing the nematode worm Caenorhabditis elegans as a model host. Bacterial diversity of the PG samples was revealed through metagenomic analysis.

Prophylactic potential of a formulation against certain pathogenic bacteria.

A preparation was evaluated for its prophylactic efficacy against bacterial infection, employing the nematode worm as a model host. Worms fed with the preparation prior to being challenged with pathogenic bacteria had a better survival rate against four out of five test bacterial pathogens, as compared to the control worms. feeding prior to bacterial challenge was found to be most effective against , resulting in 27% (p=0.