Mesotherapy for facial skin rejuvenation: a clinical, histologic, and electron microscopic evaluation.

Background And Objective: Mesotherapy, as broadly defined, represents a variety of minimally invasive techniques in which medications are directly injected into the skin and underlying tissue in order to improve musculoskeletal, neurologic, and cosmetic conditions. There are few clinical studies evaluating the efficacy and safety of mesotherapy in any form. This study evaluates the histologic and clinical changes associated with one of the simplest formulations of mesotheraphy commonly used for skin rejuvenation.

Combined 633-nm and 830-nm led treatment of photoaging skin.

Objectives: To evaluate the clinical efficacy and ultrastructural changes in photodamaged skin after combined 633-nm and 830-nm light-emitting diode (LED) treatments.

Methods: Thirty-six subjects received 9 LED treatments over the course of 5 weeks and were subsequently evaluated for final clinical improvement 12 weeks after treatment. Five subjects were also biopsied to determine the ultrastuctural posttreatment changes in collagen fibers.

Acne scar correction using calcium hydroxylapatite in a carrier-based gel.

Objectives: This study sought to determine the efficacy and safety profile of calcium hydroxylapatite filler in the treatment of acne scars.

Methods: Ten subjects with a variety of acne scars were treated with calcium hydroxylapatite filler.

Results: Saucerized acne scars responded to treatment; ice-pick scars did not.

Clinical comparison of four hair removal lasers and light sources.

Background And Objective: There are few clinical studies directly comparing the efficacy of multiple hair removal systems in the same individual. This study evaluates the efficacy of four highly popular systems for laser hair removal.

Methods: In this prospective comparison study, 10 subjects underwent treatment of unwanted hair on the back or thigh.

Mutations in the desmoglein 4 gene underlie localized autosomal recessive hypotrichosis with monilethrix hairs and congenital scalp erosions.

Localized autosomal recessive hypotrichosis (LAH) is a recently defined disorder characterized by fragile, short, sparse hairs on the scalp, trunk, and extremities. Mutations in desmoglein 4 (DSG4), a novel member of the desmosomal cadherin family that is expressed in the hair follicle as well as the suprabasal epidermis, have been found to underlie LAH. Thus far, the allelic series includes a recurrent intragenic deletion identified in affected Pakastani kindreds and a missense mutation detected in an Iraqi family.

Comparative treatment of small diameter (< or =400 microm) vascular lesions using extended pulse dye lasers.

Background And Objectives: Extended-pulse dye lasers (EPDL) are commonly used to treat a variety of vascular lesions. This study evaluated whether differences in pulse formats and cooling methods might affect outcome in the treatment of small facial telangictasia.

Study Design/materials And Methods: Ten subjects presenting with symmetric, bilateral facial telangiectasia were studied.

Topical anesthetics for cosmetic and laser dermatology.

Many effective and simple topical anesthetic products are available today and commonly used in medical and non-medical settings. The increased use of topical anesthetics, especially by non-physicians in the medical and non-medical settings, has resulted in increased rates of complications including ineffective anesthesia, allergy, and even potential fatalities. This review focuses on various techniques and formulations for topical anesthesia and their appropriate applications in cosmetic and laser dermatology.

Complications from injectable polyacrylamide gel, a new nonbiodegradable soft tissue filler.

Background: Polyacrylamide gels, containing a hydrogel composed of polyacrylamide and water, are used for soft tissue augmentation and contour correction. There are no reports of significant complications after injection of this material into the face.

Objective: We report an inflammatory reaction after injection of polyacrylamide gels for zygomatic facial augmentation.

Multiple subclinical syringomatous proliferations encountered during Mohs surgery for basal cell carcinoma.

Background: Examination of Mohs surgery frozen sections may lead to discovery of incidental benign neoplasms such as syringomas.

Objective: An unusual occurrence of numerous subclinical syringomatous proliferations discovered during Mohs surgery for a basal cell carcinoma that posed a diagnostic and management dilemma is reported.

Methods: Clinical records and histologic sections are examined.