Publications by authors named "Sneha Agarwala"
Paroxysmal Cold Hemoglobinuria: Mild to Catastrophic-Spectrum of a Rare Hemolytic Anemia of Childhood.
J Pediatr Hematol Oncol
November 2024
Article Synopsis
- Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune condition primarily affecting young children, characterized by an antibody that damages red blood cells at colder temperatures and causes lysis when warmed.
- Diagnosis involves high clinical suspicion and confirming antibodies known as Donath-Landsteiner antibodies, with symptoms potentially leading to acute kidney injury and the need for treatments like hemodialysis.
- The report highlights the importance of recognizing PCH to avoid misdiagnosis with generic autoimmune hemolytic anemia and unnecessary treatments, while also noting that it can sometimes require urgent renal replacement therapy despite being self-limiting.