30 Gbit/s PAM4 transmission using an 8-GHz directly modulated multi-section laser.

This paper describes the characterization of a novel directly modulated multi-section laser with a master-slave configuration. Amplitude and phase noise measurements show relative intensity noise values of around -150 dB/Hz and a 3-dB linewidth of around 3 MHz. The laser's suitability for optical access networks, enabled by the chirp reduction from the external injection locking, is shown by demonstrating unamplified 30 Gbit/s C-band transmission over 25 km and 50 km of single mode fiber using PAM4, as well as 30 Gbit/s PAM4 and PAM8 amplified transmission over 75 km.

InP photonic integrated externally injected gain switched optical frequency comb.

We report on an InP photonic integrated circuit for the generation of an externally injected gain switched optical frequency comb. The device is fully characterized and generates a comb with frequency spacing ranging from 6 to 10 GHz, good noise properties that include relative intensity noise of <-130  dB/Hz and linewidth of 1.5 MHz, and a high phase correlation between comb lines.

Multi-wavelength coherent transmission using an optical frequency comb as a local oscillator.

Steadily increasing data rates of optical interfaces require spectrally efficient coherent transmission using higher-order modulation formats in combination with scalable wavelength-division multiplexing (WDM) schemes. At the transmitter, optical frequency combs (OFC) lend themselves to particularly precise multi-wavelength sources for WDM transmission. In this work we demonstrate that these advantages can also be leveraged at the receiver by using an OFC as a highly scalable multi-wavelength local oscillator (LO) for coherent detection.

Flexible wavelength de-multiplexer for elastic optical networking.

We report an injection locked flexible wavelength de-multiplexer (de-mux) that shows 24-h frequency stability of 1 kHz for optical comb-based elastic optical networking applications. We demonstrate 50 GHz, 87.5 GHz equal spacing and 6.

Software reconfigurable highly flexible gain switched optical frequency comb source.

The authors present the performance and noise properties of a software reconfigurable, FSR and wavelength tunable gain switched optical frequency comb source. This source, based on the external injection of a temperature tuned Fabry-Pérot laser diode, offers quasi-continuous wavelength tunability over the C-band (30nm) and FSR tunability ranging from 6 to 14GHz. The results achieved demonstrate the excellent spectral quality of the comb tones (RIN ~-130dB/Hz and low phase noise of 300kHz) and its outstanding stability (with fluctuations of the individual comb tones of less than 0.

On the gender-science stereotypes held by scientists: explicit accord with gender-ratios, implicit accord with scientific identity.

Women's representation in science has changed substantially, but unevenly, over the past 40 years. In health and biological sciences, for example, women's representation among U.S.

A web-based examination of experiences with intrusive thoughts across the adult lifespan.

Objectives: Intrusive thoughts and images are common across the adult lifespan, but vary in their consequences. Understanding age-related experiences with intrusive thoughts is important for identifying risk and protective factors for intrusive thought problems across the adult lifespan. This study characterized age trajectories for six aspects of experiences with intrusive thoughts using Internet data collection.

Aging and repeated thought suppression success.

Intrusive thoughts and attempts to suppress them are common, but while suppression may be effective in the short-term, it can increase thought recurrence in the long-term. Because intentional suppression involves controlled processing, and many aspects of controlled processing decline with age, age differences in thought suppression outcomes may emerge, especially over repeated thought suppression attempts as cognitive resources are expended. Using multilevel modeling, we examined age differences in reactions to thought suppression attempts across four thought suppression sequences in 40 older and 42 younger adults.

Effects of phase noise of monolithic tunable laser on coherent communication systems.

We investigate the effects of different phase noise processes of SGDBR laser on coherent systems. The SGDBR device operated well with QPSK modulation at 5 Gbaud, while the performance of 16-QAM was significantly degraded due to excess noise. The white FM noise mainly defines the ultimate performance of coherent reception, but the low frequency excess noise can potentially degrade the performance of systems that employ 16-QAM format at 5 Gbaud.

Anxiety-linked expectancy bias across the adult lifespan.

Anxiety is characterised by a negative expectancy bias, such that anxious individuals report negatively distorted expectations about the future. Contrary to anxiety, ageing is characterised by a positivity effect, such that ageing is associated with a tendency to attend to and remember positive information, relative to negative information. The current study integrates these literatures to examine anxiety- and age-linked biases when thinking about the future.

Characterization of time-resolved laser differential phase using 3D complementary cumulative distribution functions.

An experimental method for characterizing the time-resolved phase noise of a fast switching tunable laser is discussed. The method experimentally determines a complementary cumulative distribution function of the laser's differential phase as a function of time after a switching event. A time resolved bit error rate of differential quadrature phase shift keying formatted data, calculated using the phase noise measurements, was fitted to an experimental time-resolved bit error rate measurement using a field programmable gate array, finding a good agreement between the time-resolved bit error rates.

A critical evaluation of HIPE data.

Resource allocation and planning of future services is dependent on current volumes, making it imperative that procedural data is accurately recorded. We sought to evaluate the effectiveness of the information gathered by the Hospital Inpatient Enquiry (HIPE) system in recording such activity. Five index vascular procedures (open/endovascular abdominal aneurysm repair, carotid endarterectomy, lower limb angioplasty/bypass) were chosen to reflect activity.

Performance improvement of 10 Gb/s direct modulation OFDM by optical injection using monolithically integrated Discrete Mode lasers.

Performance improvement of a directly modulated 10 Gb/s OFDM system by optical injection of monolithically integrated lasers is shown experimentally over differing fibre lengths. The modulation and optical injection is performed using monolithically integrated Discrete Mode lasers. It is shown that optical injection with this device reduces third order inter-modulation distortion by up to 10dB and this results in an improvement in system performance from above a forward error correction BER threshold of 1 × 10(-3) to significantly below it.

MAb 806 enhances the efficacy of ionizing radiation in glioma xenografts expressing the de2-7 epidermal growth factor receptor.

Purpose: Mutations of the epidermal growth factor receptor (EGFR) are common in glioma. The most frequent mutation, de2-7 EGFR/EGFRvIII, occurs in approximately 40% of high-grade gliomas and confers resistance to ionizing radiation (IR). We have previously shown that mAb 806, a novel EGFR-specific antibody, is able to inhibit the growth of U87MG.

Immuno-PET quantitation of de2-7 epidermal growth factor receptor expression in glioma using 124I-IMP-R4-labeled antibody ch806.

Unlabelled: Overexpression, activation, and mutations of the epidermal growth factor receptor (EGFR) are commonly found in solid tumors. The aim of this study was to develop a PET-based method for detecting the constitutively active mutant de2-7 EGFR, which is associated with disease progression and resistance to chemotherapy and radiotherapy in glioma.

Methods: The chimeric antibody ch806, which selectively binds an epitope of the EGFR that is exposed only on overexpressed, mutant, or ligand-activated forms of the receptor, was conjugated to the radiohalogen (124)I via the residualizing ligand IMP-R4, and in vitro properties were characterized.

Chronic pain in people with an intellectual disability: under-recognised and under-treated?

Aim: To examine the nature, prevalence and impact of chronic pain in adults with an intellectual disability (ID) based on carer report.

Methods: Postal questionnaires were sent to 250 care-givers and 157 responses were received (63%).

Results: Chronic pain was reported in 13% of the sample (n = 21), 6.

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen.

We have evaluated the carbohydrate antigen Lewis(Y) (Le(Y)) as a potential target for T-cell immunotherapy of hematological neoplasias. Analysis of 81 primary bone marrow samples revealed moderate Le(Y) expression on plasma cells of myeloma patients and myeloblasts of patients with acute myeloid leukemia (AML) (52 and 46% of cases, respectively). We developed a retroviral vector construct encoding a chimeric T-cell receptor that recognizes the Le(Y) antigen in a major histocompatibility complex-independent manner and delivers co-stimulatory signals to achieve T-cell activation.

Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers.

Purpose: This phase I study explored the biodistribution and pharmacokinetics of the immunoconjugate CMD-193 [a humanized anti-Lewis Y (Le(y)) antibody conjugated with calicheamicin in patients with advanced cancers expressing the Le(y) antigen.

Experimental Design: The primary objectives were to determine biodistribution and pharmacokinetics of CMD-193. Secondary objectives included response rates and change in tumor metabolism.

National differences in gender-science stereotypes predict national sex differences in science and math achievement.

About 70% of more than half a million Implicit Association Tests completed by citizens of 34 countries revealed expected implicit stereotypes associating science with males more than with females. We discovered that nation-level implicit stereotypes predicted nation-level sex differences in 8th-grade science and mathematics achievement. Self-reported stereotypes did not provide additional predictive validity of the achievement gap.

Investigation of an outbreak of Salmonella enterica serovar Newport infection.

A large outbreak of Salmonella enterica serotype Newport infection occurred in Northern Ireland during September and October 2004. Typing of isolates from patients confirmed that this strain was indistinguishable from that in concurrent outbreaks in regions of England, in Scotland and in the Isle of Man. A total of 130 cases were distributed unequally across local government district areas in Northern Ireland.

Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.

Background: This study investigated the biodistribution and therapeutic efficacy of Lutetium-177 (177Lu) radiolabeled anti-Lewis Y monoclonal antibody hu3S193 radioimmunotherapy (RIT) in mice bearing prostate cancer xenografts. The ability of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 and docetaxel chemotherapy to enhance the efficacy of RIT was also assessed in vivo.

Methods: The in vitro cytotoxicity of 177Lu labeled hu3S193 on Le(y) positive DU145 prostate cancer cells was assessed using proliferation assays, with induction of apoptosis measured by ELISA.

Larval aquatic and terrestrial mites infesting a temperate assemblage of mosquitoes.

We collected 22,769 adult female mosquitoes, representing 27 species, from light traps in Norfolk, Virginia (2006-2007) and examined them to assess infestation by larval mites. Mosquitoes were parasitized by two species of aquatic (Acari: Arrenuridae: Arrenurus) and three species of terrestrial mites (Acari: Erythraeidae). The prevalence of infestation varied from 0.