Publications by authors named "Smrithi Chidambaram"
Background: Although strongly associated with tobacco and alcohol use, many oral cavity squamous cell carcinoma (OCSCC) cases occur in patients without exposure to either, known as "never-smoker, never-drinkers" (NSND). We aimed to compare clinical outcomes between NSND and tobacco/alcohol-exposed populations and to define demographic characteristics of NSND.
Methods: We performed a retrospective, single-institution cohort study of 672 OCSCC patients.
Quantifying Total and Out-of-Pocket Costs Associated With Head and Neck Cancer Survivorship.
JAMA Otolaryngol Head Neck Surg
December 2022
Importance: Oncologic treatment is costly to the health care system and to individuals, but patients with head and neck cancer (HNC) also have long-term care needs after treatment. Survivors of HNC require specific consideration given their rapidly growing numbers. This subpopulation of cancer survivors often experiences long-term treatment-associated morbidity.
View Article and Find Full Text PDFArticle Synopsis
- This study looked at how common head and neck cancers (HNC) are in different groups of people and areas.
- They checked cancer data from 2001 to 2017 to see if the rates of these cancers were going up or down.
- They found that some types of HNC, like oropharyngeal cancer in White males, are getting less common, while oral cavity cancer in other races and White females is rising. They suggest more studies are needed to understand why these differences exist based on race and gender.
Objective: This study assesses longitudinal epidemiologic trends in the oldest head and neck cancer (HNC) patients, comparing the oropharynx to other mucosal HNC sites.
Materials And Methods: Using data from the Surveillance, Epidemiology, and End Results database, trends in incidence, two-year cancer specific mortality, and percent of cases recommended for and which received surgery from 2000 to 2018 in patients ages ≥85 years were assessed using Joinpoint analysis by HNC site. Trends were quantified as annual percentage change (APC) with 95% confidence intervals (CI).
Utilization of frontal balloon sinuplasty in pediatric complicated acute rhinosinusitis (ARS) is demonstrated to be a safe and expedient alternative to other procedures such as trephination or functional endoscopic sinus surgery (FESS) in this case series. We performed a retrospective review of six pediatric cases of frontal balloon sinuplasty for ARS with intracranial complications at a tertiary academic center. Patients underwent unilateral ( = 5) or bilateral dilation ( = 1) in addition to functional endoscopic sinus surgery (FESS) including anterior ethmoidectomy ( = 5) and maxillary antrostomy ( = 6).
View Article and Find Full Text PDFObjectives: While smoking is associated with worse outcomes in HPV-positive oropharyngeal squamous cell carcinoma (OPSCC), the magnitude of this association is unclear given the heterogenous smoking definitions and outcomes. Our objective was to investigate the association between smoking, survival, and recurrence in HPV-related OPSCC using multiple smoking metrics reported in the literature.
Materials And Methods: This was a retrospective cohort study of 375 adults with p16+ OPSCC undergoing surgical resection (n = 272) or definitive chemoradiation (n = 103) at a tertiary academic institution from 2006 to 2017.
Objective: To determine the prognostic significance of smoking in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) when considering American Joint Committee on Cancer eighth edition (AJCC-8) stage.
Study Design: Retrospective cohort study.
Methods: Three hundred seventeen HPV-positive OPSCC patients with known AJCC-8 stage and smoking status (<10 or ≥10 pack-years) seen at a tertiary center from 1997 to 2017 were studied.