Biologic Brachytherapy: Genetically Modified Surgical Flap as a Therapeutic Tool-A Systematic Review of Animal Studies.

Surgical flaps are rudimentary tools in reconstructive surgery, especially following extensive solid tumour resections. They cover skin and soft tissue defects but are prone to ischaemia and necrosis. Since their primary aim is reconstruction, they rarely exhibit a therapeutic activity against the treated disease.

Airborne particulate matter measurement and prediction with machine learning techniques.

Air quality is a fundamental component of a healthy environment for human beings. Monitoring networks for air pollution have been established in numerous industrial zones. The data collected by the pervasive monitoring devices can be utilized not only for determining the current environmental condition, but also for forecasting it in the near future.

Pre-Incisional and Multiple Intradermal Injection of N-Acetylcysteine Slightly Improves Incisional Wound Healing in an Animal Model.

The objective of this study was to investigate if delivering multiple doses of N-acetylcysteine (NAC) post-surgery in addition to pre-incisional administration significantly impacts the wound healing process in a rat model. Full-thickness skin incisions were carried out on the dorsum of 24 Sprague-Dawley rats in six locations. Fifteen minutes prior to the incision, half of the sites were treated with a control solution, with the wounds on the contralateral side treated with solutions containing 0.

Towards Symmetric Thioamides: Microwave-Aided Synthesis of Terephthalic Acid Derivatives.

The multistep synthesis of novel -terephthalthioamides based on methyl esters of amino acids (AAs) was proposed using conventional heating and microwave-assisted approaches. In fact, the comparative case study on the thionation of new symmetrical diamides with Lawesson's reagent (LR) was performed. The microwave-accelerated small-scale methodology was successfully employed on the whole pathway from substrates (Gly, Ala, Val, Tyr, Ser) to products (symmetrical dithioamides of terephthalic acid), resulting in significantly reduced reaction time, energy requirements, and slightly increased reaction yields when compared to conventional heating.

Utilization of Carbon Dioxide and Fluidized Bed Fly Ash in Post-Industrial Land Remediation.

The utilization of carbon dioxide and combustion products in cost- and energy-efficient technologies is an important element of creating sustainable energy systems, particularly in the transition period towards carbon neutrality and in light of the latest political developments, when solid fuels are still competing for a dominant role in securing energy supplies. Within the study presented, bituminous coal-derived fluidized bed fly ash samples of high calcium content, treated using a dry carbonation method under ambient conditions, were tested in terms of their specific properties to determine their usability in the preparation of injection mixtures for the filling of voids after shallow mining activities and other selected geo-engineering techniques. The study goes beyond the existing literature in terms of the carbonation method used, alkaline earth metal source, scale of the experiment, process conditions employed and product application studied.

Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated -arylcinnamamides.

A series of seventeen 4-chlorocinnamanilides and seventeen 3,4-dichlorocinnamanilides were characterized for their antiplasmodial activity. In vitro screening on a chloroquine-sensitive strain of 3D7/MRA-102 highlighted that 23 compounds possessed IC < 30 µM. Typically, 3,4-dichlorocinnamanilides showed a broader range of activity compared to 4-chlorocinnamanilides.

In-situ experimental study on hydro-borehole technology application to improve the hard coal excavating techniques in coal mine.

The hydro-mining technology is considered as a promising method of bituminous coal excavation. The paper presents the results of the in-situ experimental campaign and modelling of hydro-cutting technology application. The proposed innovative technology was tested in terms of the effects of the distance between the outlet of water from the nozzle and a sidewall, pressure of the water jet, as well as the type of a nozzle on hydro-mining effectiveness.

Implementing Silica Nanoparticles in the Study of the Airborne Transmission of SARS-CoV-2.

Aerosol transmission constitutes one of the major transmission routes of the SARS-CoV-2 pathogen. Due to the pathogen's properties, research on its airborne transmission has some limitations. This paper focuses on silica nanoparticles (SiO) of 40 and 200 nm sizes as the physicochemical markers of a single SARS-CoV-2 particle enabling experiments on the transmission of bioaerosols in public spaces.

Multi-Case Study on Environmental and Economic Benefits through Co-Burning Refuse-Derived Fuels and Sewage Sludge in Cement Industry.

The use of waste as an energy source in cement clinker production is a promising way to transition toward a circular economy and limit carbon dioxide (CO) in the atmosphere. The cement industry is responsible for around 5% of global CO emissions. In this paper, the analysis of environmental and economic profits associated with the substitution of coal by two refuse-derived fuels (RDF) and sewage sludge (SS) in a cement kiln was presented.

Improved method of fire hazard assessment taking into account the effect of the primary temperature of a coal seam on the desorption ratio of gas indicators.

The methods of fire risk assessment in its early phase employed so far used to take into account only the temperature of the heating of coal. The research works reported so far in this field have been conducted at ambient temperatures, without considering the rock mass primary temperature occurring in a particular coal seam and neglecting the depth of coal seams. The method for the determination of the composition of gases emitted from coal samples, employed in the study presented here, takes into account the effect of rock mass pressure, and therefore the depth of the coal seam, as well as the temperature typical for the rock mass in a particular coal mine.

CFD Numerical Modelling of a PV-TEG Hybrid System Cooled by Air Heat Sink Coupled with a Single-Phase Inverter.

This study presents full transient, three-dimensional numerical models of a PV-TEG hybrid module coupled with single-phase inverter by co-simulation. The influence of factors, such as wind speed, solar radiation intensity, or ambient temperature on the PV-TEG system, was also examined. The numerical model was implemented using Ansys software which accounted the phenomena of Thomson, Seebeck, and Joule's heat place on the TEG system.

Continuous Automated Model EvaluatiOn (CAMEO)-Perspectives on the future of fully automated evaluation of structure prediction methods.

The Continuous Automated Model EvaluatiOn (CAMEO) platform complements the biennial CASP experiment by conducting fully automated blind evaluations of three-dimensional protein prediction servers based on the weekly prerelease of sequences of those structures, which are going to be published in the upcoming release of the Protein Data Bank. While in CASP14, significant success was observed in predicting the structures of individual protein chains with high accuracy, significant challenges remain in correctly predicting the structures of complexes. By implementing fully automated evaluation of predictions for protein-protein complexes, as well as for proteins in complex with ligands, peptides, nucleic acids, or proteins containing noncanonical amino acid residues, CAMEO will assist new developments in those challenging areas of active research.

The feasibility of CO emission reduction by adsorptive storage on Polish hard coals in the Upper Silesia Coal Basin: An experimental and modeling study of equilibrium, kinetics and thermodynamics.

Carbon dioxide storage in unmineable coal seams is advantageous in the highly industrialized areas, such as the Upper Silesia Coal Basin (USCB), Poland, where heavy industry constitutes the source of huge CO emissions and coal mines will be closed in the future, due to unprofitability. The paper presents the results of experimental and theoretical research of CO capture on medium rank C and B bituminous coals coming from three mines located in the USCB. The porous texture of the investigated adsorbents was analyzed using SEM images and the N and CO isotherms at -196 °C and 0 °C, respectively.

Transport of Aerosols in Underground Mine Workings in Terms of SARS-CoV-2 Virus Threat.

This paper presents a method of implementation and the results of aerosol dispersion tests in underground mine workings. Numerous tests were carried out to determine the potential risk of SARS-CoV-2 coronavirus infection in the underground environment of the mines. The influence of selected parameters of mine air on the possibility and method of aerosol transmission through ventilation routes was experimentally determined in real conditions.

Functional and Material Properties in Nanocatalyst Design: A Data Handling and Sharing Problem.

(1) Background: Properties and descriptors are two forms of molecular in silico representations. Properties can be further divided into functional, e.g.

New Method for Analysis of the Temporomandibular Joint Using Cone Beam Computed Tomography.

Modern dentistry commonly uses a variety of imaging methods to support diagnosis and treatment. Among them, cone beam computed tomography (CBCT) is particularly useful in presenting head structures, such as the temporomandibular joint (TMJ). The determination of the morphology of the joint is an important part of the diagnosis as well as the monitoring of the treatment results.

An analysis of self-ignition of mine waste dumps in terms of environmental protection in industrial areas in Poland.

The aim of the paper was to work out a new comprehensive methodology to monitor thermal activity at mine waste dumps. The methodology was tested through monitoring thermal phenomena occurring in the areas of extractive waste dumping facilities located in the Upper Silesian Coal Basin, Poland. Within the framework of the study, a comparative analysis of three waste dumps was performed; the first two of them, which were not previously reclaimed, are in part thermally active, whereas the third one comprises one section which was partially reclaimed and another section which is still being operated.

Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors.

A library of novel 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides was designed and synthesized in order to provide potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors; the in vitro inhibitory profile and selectivity index were specified. Benzyl (3-hydroxy-4-{[2-(trifluoromethoxy)phenyl]carbamoyl}phenyl)carbamate was the best AChE inhibitor with the inhibitory concentration of IC = 36.05 µM in the series, while benzyl {3-hydroxy-4-[(2-methoxyphenyl)carbamoyl]phenyl}-carbamate was the most potent BChE inhibitor (IC = 22.

The application of hierarchical clustering to analyzing ashes from the combustion of wood pellets mixed with waste materials.

Air pollution constitutes the greatest environmental threat to human health in the European Union. In Poland, the emission of particulate matter and harmful gases originating from local coal based boiler plants and the combustion of fuels in residential heating appliances is a considerable source of air pollution. The combustion of fuel in home furnaces is inefficient due to the use of cheap fuels of low heating parameters and the frequent addition of waste.

Process Kinetics of the Carbonation of Fly Ashes: A Research Study.

The aim of the paper is to present the results of research on the carbonation process kinetics of coal combustion ashes originating from fluidized bed boilers used in power plants. Based on the thermogravimetric analysis (TGA), the hypothesis that carbon dioxide is bounded by the mineral substances (calcium compounds) in the fly ashes was confirmed. Determining the kinetic parameters of the carbonation of fly ashes requires simultaneously taking into consideration the kinetics of the drying process of the sample.

Laminar analysis of the cerebellar cortex shows widespread damage in early MS patients: A pilot study at 7T MRI.

Background: To date, little is known about the presence and extent of cerebellar cortical pathology in early stages of MS.

Objective: The aims of this study were to (i) investigate microstructural changes in the normal-appearing cerebellar cortex of early MS patients by using 7 T MRI and (ii) evaluate the influence of those changes on clinical performance.

Methods: Eighteen RRMS patients and nine healthy controls underwent quantitative T and T* measurement at 7 T MRI using high-resolution MP2RAGE and multi-echo gradient-echo imaging.

Estimation of Dense Plasma Temperature Formed under Shock Wave Cumulation.

The research was carried out by means of implosion plasma generators with conical and hemispherical compression chambers to conduct a quantitative assessment of the boundary temperature of super dense plasma jets. It was proved experimentally that nuclear transformations in metals are caused by the impact of super dense plasma jets (11, ..

Biomechanical Testing of a Transmetatarsal Base Screw in Lisfranc Injuries.

Objectives: To compare displacement between the cuneiforms and metatarsals for a typical Lisfranc screw and a transmetatarsal base screw under biomechanical loading.

Methods: Eight pairs of cadaveric feet (16 total) were evaluated. The Lisfranc ligamentous structures were transected in all specimens.

The impact of alder litter on chemistry of Technosols developed from lignite combustion waste and natural sandy substrate: a laboratory experiment.

Alders, as an N-fixing species, are widely used as a phytomelioration species at post-industrial sites. The paper presents the effects of litter decomposition of different alder species-black alder, gray alder, and green alder-on changes to the soil solution chemistry of Technosols developed from two types of substrates: lignite combustion waste and sandy substrates from a former sand quarry. Under controlled conditions, the 13-week experiment investigated pH, electrical conductivity (EC), and the chemical parameters-dissolved organic carbon (DOC), dissolved nitrogen (DON), and macroelements S, Ca, Mg, K, and Na content-of filtrates in composites consisting of substrate and litter from alder species was investigated.

Biological Activities and ADMET-Related Properties of Novel Set of Cinnamanilides.

A series of nineteen novel ring-substituted -arylcinnamanilides was synthesized and characterized. All investigated compounds were tested against as the reference strain, two clinical isolates of methicillin-resistant (MRSA), and . (2)--[3-Fluoro-4-(trifluoromethyl)phenyl]-3-phenylprop-2-enamide showed even better activity (minimum inhibitory concentration (MIC) 25.