[Means to improvement of epidemiologic control of indication of causative agents of infectious diseases].

The system of indication ofbiological pathogens that exists in our country allows to implement efficacious monitoring of epidemiologic situation, timely detect causative agents of infectious and parasitic diseases in material from humans and environmental samples, conduct their detailed identification and take appropriate means to ensure biosafety of the Russian Federation.

[Information technologies in epidemiological control of natural-focal infectious diseases].

An approach to increase effectiveness of epidemiological control of Crimean hemorrhagic fever, West Nile fever and Astrakhan spotted fever by building a prognostic model of epidemic activity based on contemporary information technologies of spatial and intellectual data analysis was developed and tested. Personified data on 4505 laboratory confirmed cases of natural-focal infectious diseases registered in the Russian Federation and database on 1999 - 2011 climatic observations were processed. A model implementing prognosis of epidemiological situation intensity level as a function of a combination of factors, maps of density of epidemic manifestations were built.

[Topical issues of biological safety under current conditions. Part 2. Conceptual, terminological, and definitive framework of biological safety].

In accordance with the established conceptual base for the up-to-date broad interpretation of biological safety, and IHR (2005), developed is the notional, terminological, and definitive framework, comprising 33 elements. Key item of the nomenclature is the biological safety that is identified as population safety (individual, social, national) from direct and (or) human environment mediated (occupational, socio-economic, geopolitical infrastructures, ecological system) exposures to hazardous biological factors. Ultimate objective of the biological safety provision is to prevent and liquidate aftermaths of emergency situations of biological character either of natural or human origin (anthropogenic) arising from direct and indirect impact of the biological threats to the public health compatible with national and international security hazard.

[Conceptual bases of biological safety. Part 1].

Up to date there is a narrow and broad interpretation of the term biological safety (BS) the world over. In the narrow sense it is defined as availability of international regulations applied to diagnostic, manufacturing, or experimental works with pathogenic biological agents (PBA) in accordance with specified levels of biological hazard and BS. In a broader context it has no national, conceptual, terminological or defying basis.

[A functional subsystem of sanitary-and-epidemiological situation surveillance of the unified state system for prevention and elimination of emergence situations].

Mass destructions of the social infrastructure and household systems under stressors in the areas of emergency situations involve marked sanitary-and-epidemiological problems in a region's population, which in turn give rise to the activation of routes of transmission and formation of infectious and parasitic diseases. The most important lines of activities of supervising the sanitary-and-epidemiological situation under emergencies are to timely assess the sanitary-and-epidemiological situation, to predict, to organize, and to correct sanitary-and-antiepidemic measures.

[Role of the priority national health project in implementing HIV epidemic control strategy in the Russian Federation].

According to the data of the UN AIDS control program, the estimated number of persons living with HIV infection worldwide is close to 36 million. There is only one way to reduce HIV infection treatment and care costs; this is to develop large-scale HIV prevention programs. The geography of the HIV infection epidemic is inhomogeneous; about 70% of the absolute number of all notified HIV cases are concentrated in 15 subjects of Russia; bulk of them are industrially developed high-income areas.

[Measures to reduce the prevalence of tobacco dependence].

In 1977, the American Cancer Society established the International No Smoking Day on the third Thursday of November. It has been celebrated in Russia since 1992. According to a WHO report, 100 million people died from smoking in the 20th century worldwide.

[Epidemiological surveillance over the organization and performance of immunoprophylaxis in the Russian Federation].

Vaccine prophylaxis is the most accessible and economic way of protecting and promoting the population's health, which is the most important part of prophylactic direction of modern medicine. The accumulated experience of mass immunization suggests the ability of a vaccine to cause 80, 96, and 92% reductions in the number of disease cases, the rate of admissions, and mortality rates, respectively.

[Design of experimental approaches on the base of standard proteins for testing blood biopreparations and immunoperoxidase conjugates specific to human and animal immunoglobulines G].

Using standard forms of immunoglobulin (Ig) G and albumin, we have studied electrophoretic and chromatographic profiles of samples of pharmaceutical blood biopreparation batches. The usability of standard proteins was also demonstrated by testing analytical characteristics of immunoperoxidase conjugates specific to human and animal IgG (anti-IgG IPC). In particular, we suggest an additional estimation of analytical characteristics of anti-IgG IPC by the enzyme reaction kinetics with the standard dilution which is calculated by the direct enzyme-liked immunoassay on the homologous IgG-antigen.

[The nucleotide sequences of the HN gene and F gene fragment of Newcastle disease virus strains BOR74 and BOR82].

The complete nucleotide sequence of HN gene, the region of F gene, and intergene regions (M-F, F-HN, and HN-L) of the BOR74 and BOR82 strains of Newcastle disease virus have been determined. Based on the nucleotide and amino acid sequences, the speeds of the nucleic and amino acid changes were calculated (approximately 10(-3) nucleotides or amino acids/year). The BOR strains were grouped phylogenetically with the asymptomatic strains.

[Effect of tranquilizers on lipid peroxidation of biological membranes].

Thirty-seven patients with unstable angina pectoris were treated with prolonged-action nitrates for 20 days; 8 of these received additionally meprobamate in a dose of 0.4 g per day and 11 patients received phenazepam in a dose of 0.002 g per day.