Correlation between tumour biology status measured in triple-tracer 18F-fluorodeoxyglucose-18F-fluorothymidine- 18F-fluoromisonidazole-PET/CT study and human papillomavirus status in patients with head and neck cancer.

Objective: Human papillomavirus (HPV) has been usually associated with gynaecological cancers; however, recent studies have shown that this virus plays an important role in head and neck cancer. The aim of this study was to correlate PET/CT parameters in HPV-positive (HPV) and HPV-negative (HPV) patients using three tracers showing glucose metabolism, proliferation and hypoxia.

Patients And Methods: Thirty-six patients (10 females and 26 males) with newly diagnosed head and neck cancer were enroled to this retrospective study.

Ruthenium Complexes Bearing Thiophene-Based Unsymmetrical N-Heterocyclic Carbene Ligands as Selective Catalysts for Olefin Metathesis in Toluene and Environmentally Friendly 2-Methyltetrahydrofuran.

Three mono-N-heterocyclic carbene (NHC) ruthenium 2-isopropoxybenzylidene (10 a-c) and one bis(NHC) indenylidene complex (8) bearing an unsymmetrical N-heterocyclic carbene ligand were synthesized and structurally characterized by single-crystal X-ray diffraction. The catalytic activity of the newly obtained complexes were evaluated in ring-closing metathesis (RCM) and ene-yne (RCEYM) reactions in toluene and environmentally friendly 2-MeTHF under air. The results confirmed that although all tested reactions can be successfully mediated by catalysts 10 a-c, their general reactivity is lower than the benchmark all-purpose Ru catalysts with symmetrical NHC ligands.