Communicating certainty via verbal probability phrases: comparing health contexts with no context.

Introduction: Medical professionals often use verbal phrases to communicate uncertainties and certainties with their patients and the general public.

Objectives: This study aimed to investigate factors that can influence people's interpretation of probability phrases of certainty and uncertainty communicated by doctors in health and medical settings.

Methods: An experimental study with a randomized factorial design was conducted to examine both context-related factors and individual difference factors on participants' interpretation across directions of phrases and frames of the context.

Expedited discharge and risk of readmission after ostomy construction.

Background: Expedited discharge after surgery with construction of an ostomy may leave patients less prepared for home self-care, leading to increased hospital readmissions. We evaluated whether readmission rates were greater for patients with an expedited discharge (1-2 days) compared with nonexpedited discharge (3-5 days) after ostomy construction.

Methods: A retrospective analysis of a prospective database of patients undergoing ostomy construction was performed using the American College of Surgeons National Safety and Quality Improvement Project data between years 2019 and 2020.

School Refusal Behaviors: The Roles of Adolescent and Parental Factors.

School refusal behaviors in adolescents have deleterious immediate and long-term consequences and are associated with mental ill-health such as anxiety and depression. Understanding factors that place youth at higher risk of school refusal behavior may assist in developing effective management approaches. We investigated parental and adolescent factors that may be associated with school refusal behaviors by specifically focusing on the role of parental and adolescent emotion dysregulation, their anxiety and depression, and parental rearing style.

Molecular differentiation between complete and incomplete responders to neoadjuvant therapy in rectal cancer.

Background: Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer, but only 20-40% of patients completely respond to this treatment.

Methods: To define the molecular features that are associated with response to nCRT, we generated and collected genomic and transcriptomic data from 712 cancers prior to treatment from our own data and from publicly available data.

Results: We found that patients with a complete response have decreased risk of both local recurrence and future metastasis.

ST6GAL1 is associated with poor response to chemoradiation in rectal cancer.

Introduction: Colorectal cancer is the third most common cause of cancer death. Rectal cancer makes up a third of all colorectal cases. Treatment for locally advanced rectal cancer includes chemoradiation followed by surgery.

The receiver operating characteristic area under the curve (or mean ridit) as an effect size.

Several authors have recommended adopting the receiver operator characteristic (ROC) area under the curve (AUC) or mean ridit as an effect size, arguing that it measures an important and interpretable type of effect that conventional effect-size measures do not. It is base-rate insensitive, robust to outliers, and invariant under order-preserving transformations. However, applications have been limited to group comparisons, and usually just two groups, in line with the popular interpretation of the AUC as measuring the probability that a randomly chosen case from one group will score higher on the dependent variable than a randomly chosen case from another group.

Racial Differences in Aging-Related Deficits Among Older Adults With Colorectal Cancer.

Background: Despite the known influences of both race- and aging-related factors in colorectal cancer outcomes and mortality, limited literature is available on the intersection between race and aging-related impairments.

Objective: To explore racial differences in frailty and geriatric deficit subdomains among patients with colorectal cancer.

Design: Retrospective study using data from the Cancer and Aging Resilience Evaluation registry.

Understanding Australian Government Risk Communication Early in the COVID-19 Pandemic: Sociodemographics, Risk Attitudes and Media Consumption.

Effective risk communication is essential for government and health authorities to effectively manage public health during the Coronavirus disease (COVID-19) pandemic. Understanding the factors that influence people's perceptions of crisis-related risk messages is critical to identify gaps and inequalities in population risk communication. Using a longitudinal survey of a representative adult sample, we examined risk communication about COVID-19 during April-June 2020 in Australia across sociodemographic groups especially the at-risk groups, accounting for and exploring the effects of risk attitudes and media engagement.

Pearls and Pitfalls for Surgical Investigators in Basic and Translational Research.

Surgeon-scientists are uniquely positioned to contribute to our understanding of the fundamental biology of surgical disease and to bring a unique perspective that leads to innovation in the diagnosis and treatment of many conditions. However, it is broadly recognized that due to the changing landscape of surgery and science, the surgeon-scientists of today face multiple challenges in this pursuit. Today, surgeon-scientists face an increased pressure from their department and hospital to generate clinical revenue, decreased availability of grant funding, greater administrative burden, rising complexity of fundamental research, increased medical school debt, and a growing desire for work-life balance.

Risk tolerance and changes in coronavirus disease (COVID) related health behaviors: A longitudinal study.

Objective: The present study examined behavioral responses during the coronavirus disease 2019 (COVID-19) pandemic and the role of dispositional risk tolerance in the Australian context.

Method: The study involved a six-wave longitudinal investigation with a nationally representative sample of Australians ( = 1,296). Dispositional risk tolerance was measured at Wave 1 and participants' anxiety level and self-report implementation of 10 COVID actions was assessed in each wave.

Using the H-index as a factor in the promotion of surgical faculty.

Introduction: Academic productivity is an important determinant for promotion. However, the measurement of academic productivity is ill-defined. The aim of this study is to demonstrate the academic productivity at the time of promotions at our institution.

The Psychological Benefits of an Uncertain World: Hope and Optimism in the Face of Existential Threat.

We examine how prior mental health predicts hopes and how hopes predict subsequent mental health, testing hypotheses in a longitudinal study with an Australian nation-wide adult sample regarding mental health consequences of the COVID-19 outbreak during its initial stage. Quota sampling was used to select a sample representative of the adult Australian population in terms of age groups, gender, and geographical location. Mental health measures were selected to include those with the best psychometric properties.

Inhibition of DNA-PK may improve response to neoadjuvant chemoradiotherapy in rectal cancer.

Treatment of locally advanced rectal cancer includes chemoradiation and surgery, but patient response to treatment is variable. Patients who have a complete response have improved outcomes; therefore, there is a critical need to identify mechanisms of resistance to circumvent them. DNA-PK is involved in the repair of DNA double-strand breaks caused by radiation, which we found to be increased in rectal cancer after treatment.

Compositional data analysis tutorial.

This article presents techniques for dealing with a form of dependency in data arising when numerical data sum to a constant for individual cases, that is, "compositional" or "ipsative" data. Examples are percentages that sum to 100, and hours in a day that sum to 24. Ipsative scales fell out of fashion in psychology during the 1960s and 1970s due to a lack of methods for analyzing them.

Sialyltransferase ST6GAL-1 mediates resistance to chemoradiation in rectal cancer.

Locally advanced rectal cancer is typically treated with chemoradiotherapy followed by surgery. Most patients do not display a complete response to chemoradiotherapy, but resistance mechanisms are poorly understood. ST6GAL-1 is a sialyltransferase that adds the negatively charged sugar, sialic acid (Sia), to cell surface proteins in the Golgi, altering their function.

Cause or symptom? A longitudinal test of bidirectional relationships between emotion regulation strategies and mental health symptoms.

Previous work has generally conceptualized emotion regulation as contributing to mental health outcomes, and not vice versa. The present study challenges this assumption by using a prospective design to investigate the directionality of underlying relationships between emotion regulation and mental health in the context of a major population-level stressor. We surveyed a large nationally representative sample of adults (18-91 years, = 704) at three 1-month intervals across the acute lockdown phase of the COVID-19 pandemic in Australia, using standardized measures of depression and anxiety symptoms.

Ileostomy Patients Using Patient Engagement Technology Experience Decreased Length of Stay.

Patients who undergo colorectal surgery, particularly, construction of a new ileostomy, are known to have longer length of stay (LOS) and increased readmissions. With the increased availability of patient engagement technology (PET), we hypothesized that because PET facilitates education before and after surgery, ileostomy patients who used PET would have decreased LOS without increasing readmissions. Variables were obtained from the National Surgical Quality Improvement Program (NSQIP) database for patients undergoing ileostomy construction.

NIH Funding of Researchers in Surgery: Decreased Career Development Awards Over Time.

Background: Over time, NIH funding has become increasingly competitive. In addition, academic surgeons' research competes with time required for patient care, operating, and administrative work. Due to these competing interests for surgeons, we hypothesize that the percentage of NIH grants awarded to researchers from departments of surgery is decreasing.

Corrigendum: The Effect of COVID-19 on Mental Health and Wellbeing in a Representative Sample of Australian Adults.

[This corrects the article DOI: 10.3389/fpsyt.2020.

The Effect of COVID-19 on Mental Health and Wellbeing in a Representative Sample of Australian Adults.

There is minimal knowledge about the impact of large-scale epidemics on community mental health, particularly during the acute phase. This gap in knowledge means we are critically ill-equipped to support communities as they face the unprecedented COVID-19 pandemic. This study aimed to provide data urgently needed to inform government policy and resource allocation now and in other future crises.

Between-Generation Phenotypic and Epigenetic Stability in a Clonal Snail.

Epigenetic variation might play an important role in generating adaptive phenotypes by underpinning within-generation developmental plasticity, persistent parental effects of the environment (e.g., transgenerational plasticity), or heritable epigenetically based polymorphism.

Measuring children's auditory statistical learning via serial recall.

Statistical learning (SL) has been a prominent focus of research in developmental and adult populations, guided by the assumption that it is a fundamental component of learning underlying higher-order cognition. In developmental populations, however, there have been recent concerns regarding the degree to which many current tasks reliably measure SL, particularly in younger children. In the current article, we present the results of two studies that measured auditory statistical learning (ASL) of linguistic stimuli in children aged 5-8 years.

Impact of uncertainty and ambiguous outcome phrasing on moral decision-making.

The literature has shown that different types of moral dilemmas elicit discrepant decision patterns. The present research investigated the role of uncertainty in contributing to these decision patterns. Two studies were conducted to examine participants' choices in commonly used dilemmas.

Regional epigenetic variation in asexual snail populations among urban and rural lakes.

Epigenetic variation has the potential to influence environmentally dependent development and contribute to phenotypic responses to local environments. Environmental epigenetic studies of sexual organisms confirm the capacity to respond through epigenetic variation. An epigenetic response could be even more important in a population when genetic variation is lacking.