Publications by authors named "Smitha Chander"
Article Synopsis
- Genetic markers are essential for diagnosing and predicting outcomes in hematological malignancies, with conventional cytogenetic study (CCS) traditionally being the standard method for over 50 years.
- A study comparing FISH (Fluorescence in Situ Hybridization) to CCS found that FISH had a significantly higher diagnostic yield, detecting abnormalities in 39.8% of cases versus 17.9% for CCS.
- While FISH proved particularly beneficial for chronic lymphocytic leukaemia (CLL), it was less effective for myelodysplastic syndrome (MDS), suggesting that both FISH and CCS have unique strengths and should be used together or separately based on the specific type of hematological malignancy.