Publications by authors named "Smiljana Paras"
Objectives: This study aimed to evaluate the intensity of the subacute local biological effects after implantation and osseoconductive potential of novel hydroxyapatite-based bone substitute coated with poly (lactide-co-glycolide), named ALBO-OS, in comparison to Bio-Oss.
Methods: Fifteen male Wistar rats, randomly assigned into groups: 10, 20, and 30 days (n꞊5), were subcutaneously implanted with ALBO-OS and Bio-Oss. Furthermore, artificially made bone defects on both rat's tibias were implanted with experimental materials.
Pyrophyllite is the least studied natural clay in terms of its potential in biomedical applications, although there are many deposits of this aluminosilicate around the world. Genotoxicity study was performed in vitro for this mineral. Subsequently, Wister rats were exposed to the pyrophyllite micronized to below 100 µm.
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- The study investigated the impact of heat stress on the pituitary-adrenal axis in broilers and explored whether early-age thermal conditioning (ETC) and vitamin C could mitigate these effects.
- Four groups of one-day-old broilers were created: a control group, a group receiving vitamin C, a group exposed to ETC, and a group combining both treatments.
- Results showed that the combination of ETC and vitamin C significantly increased the area and core size of adrenocorticotropic hormone (ACTH) cells and cortisol levels, suggesting enhanced adaptation to heat stress in the T + C group.
The effects of a new material based on hydroxyapatite and calcium silicates, named ALBO-MPCA, were investigated on the liver, kidney and spleen. The material was administrated orally for 120 days in an in vivo model in Wistar rats, and untreated animals served as a control. Hematological and biochemical blood parameters were analyzed.
View Article and Find Full Text PDFNovel three-dimensional (3D) nanohydroxyapatite-PLGA scaffolds with high porosity was developed to better mimic mineral component and microstructure of natural bone. To perform a final assessment of this nanomaterial as a potential bone substitute, its toxicological profile was particularly investigated. Therefore, we performed a comet assay on human monocytes for in vitro genotoxicity investigation, and the systemic subchronic toxicity investigation on rats being per oral feed with exactly administrated extract quantities of the nano calcium hydroxyapatite covered with tiny layers of PLGA (ALBO-OS) for 120 days.
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- This case report discusses a rare mixed infection in a European wildcat caused by two parasitic species: Aelurostrongylus abstrusus and Angiostrongylus chabaudi, marking the first documented instance of this in Bosnia and Herzegovina.
- The wildcat experienced severe health issues, including bronchopneumonia and infections from additional gastrointestinal parasites like Toxocara cati, highlighting the serious effects of these parasites in wildlife.
- The study provides a thorough examination of the bronchopneumonia's pathology, details the morphology of the parasites, and employs molecular techniques like triplex PCR to confirm the diagnosis, expanding understanding of these neglected parasites' impact on European wildcats.