Features of differential cytological diagnosis of primary and metastatic liver carcinoma.

The aim of the work was to assess the possibility of the cytological method in the diagnosis of epithelial liver tumors and to determine the cytomorphological criteria in the differential diagnosis of liver carcinomas. The authors analyzed the data of 106 fine-needle aspiration biopsies and 167 smears-prints during cor-biopsy of masses of the liver in patients who were examined at the polyclinic of the oncological dispensary in Nizhny Novgorod in 2016. - 2017 As a result, full-fledged material for cytological examination in the form of smears-prints from cor-biopsy and fine-needle aspiration biopsies was obtained in 75.

Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of and Genera.

Low molecular weight secondary metabolites of marine fungi , and sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques.

[Dynamics of crystallogenic properties of the oral fluid and periodontal status when using toothpaste with fluoride].

Unlabelled: The of the study was to assess the efficacy of parodontax complex anti-inflammatory toothpaste with fluorine for treatment of moderate catarrhal gingivitis.

Material And Methods: Within 6 weeks a group of students was observed, which was divided into 2 subgroups depending on the activity of the carious process and with characteristic changes in crystalloscopy of the oral fluid. Clinical trials of parodontax anti-inflammatory toothpaste with fluorine were conducted.

Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus .

Seven known echinulin-related indolediketopiperazine alkaloids (-) were isolated from the Vietnamese sediment-derived fungus . Using chiral HPLC, the enantiomers of cryptoechinuline B () were isolated as individual compounds for the first time. (+)-Cryptoechinuline B () exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease.

Biologically Active Metabolites from the Marine Sediment-Derived Fungus .

Four new compounds were isolated from the Vietnamese marine sediment-derived fungus , one aspyrone-related polyketide aspilactonol G (), one meroterpenoid 12-epi-aspertetranone D (), two drimane derivatives (,), together with five known metabolites (,,,,,). The structures of compounds - were established by NMR and MS techniques. The absolute stereoconfigurations of compounds and were determined by a modified Mosher's method.

Citriperazines A-D produced by a marine algae-derived fungus sp. KMM 4672.

Four new diketopiperazine alkaloids, citriperazines A-D were isolated from algae-derived sp. KMM 4672. The structures of compounds were determined using spectroscopic methods.

Auroglaucin-related neuroprotective compounds from Vietnamese marine sediment-derived fungus .

Two new auroglaucin-derived compounds, niveoglaucins A () and B (), together with four known related compounds were isolated from extract of the marine sediment-derived strain of . The structures of these compounds were determined by 1D and 2D NMR spectroscopy and high resolution MS. The plausible biosynthetic pathway was proposed for new compounds and .

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson's Disease Models.

A new melatonin analogue 6-hydroxy--acetyl-β-oxotryptamine () was isolated from the marine-derived fungus sp. KMM 4672. It is the second case of melatonin-related compounds isolation from microfilamentous fungi.

Asperindoles A⁻D and a -Terphenyl Derivative from the Ascidian-Derived Fungus sp. KMM 4676.

Four new indole-diterpene alkaloids asperindoles A⁻D (⁻) and the known -terphenyl derivative 3″-hydroxyterphenyllin () were isolated from the marine-derived strain of the fungus sp., associated with an unidentified colonial ascidian. The structures of ⁻ were established by 2D NMR and HRESIMS data.

Influence of the Metabolites of the Marine Algicolous Fungus Penicillium sp. on Seedling Root Growth of Agricultural Plants.

N-Methylpretrichodermamide B (I), pretrichodermamide C (H), quinolactacide (III) and 8-methoxy-3,5-dimethyl-3,4-dihydro-IH-isochromen-6-ol (IV), isolated from the marine fungus Penicillium sp., were examined for their ability to stimulate growth of seedling roots of buckwheat (Fagopyrum esculentum Moench), wheat (Triticum aestivum L.), soy {Glycine max (L.

Pretrichodermamides D-F from a Marine Algicolous Fungus Penicillium sp. KMM 4672.

Three new epidithiodiketopiperazines pretrichodermamides D-F (1-3), together with the known N-methylpretrichodermamide B (4) and pretrichodermamide С (5), were isolated from the lipophilic extract of the marine algae-derived fungus Penicillium sp. KMM 4672. The structures of compounds 1-5 were determined based on spectroscopic methods.

New Metabolites from a Marine Sediment-Derived Fungus, Aspergillus carneus.

A new polyketide 1 and a new decaline derivative 2 were isolated from a sediment-derived fungus Aspergillus carneus Blochwitz, together with one known bisabolane sesquiterpenoid and seven known polyketide metabolites. The structures of the isolated compounds were established by HR-MS, and 1D and 2D NMR spectroscopy. The cytotoxic and antiradical activities of the isolated compounds were evaluated.

Oxirapentyns A, B and E from the marine-derived strain of Isaria felina KMM 4639 as stimulators of initial stages of development of agricultural plants.

Oxirapentyn A (1), oxirapentyn B (2), and oxirapentyn E (3) were examined for their ability to stimulate growth of seedling roots of barley (Hordeum vulgare L.), buckwheat (Fagopyrum esculentum Moench), corn (Zea mays L.), soy {Glycine max (L.

Oxirapentyns F-K from the marine-sediment-derived fungus Isaria felina KMM 4639.

Six new highly oxygenated chromene derivatives, oxirapentyns F-K (2-7), one new polyketide (8), one new benzofurane (9), and two known cyclodepsipeptides, isoisariin B and isaridin E, were isolated from the lipophilic extract of the marine-derived fungus Isaria felina KMM 4639. The structures of compounds 2-9 were determined using spectroscopic methods. The relative configurations of compounds 2-7 were established through a combination of NOE data and spin coupling constants, and these results were confirmed by X-ray crystallographic analysis of 4.

Decumbenone C, a new cytotoxic decaline derivative from the marine fungus Aspergillus sulphureus KMM 4640.

A new decaline derivative, decumbenone C (1) along with four known compounds, decumbenones A (2) and B (3), diorcinol (4), and brevianamide F (5) were isolated from the marine fungus Aspergillus sulphureus KMM 4640. Decumbenone C shows potent cytotoxic activity against SK-MEL-5 human melanoma cells with IC(50) values of 0.9 μM.

[Influence of hazardous work conditions of chemical production on health state of the aged workers].

Influence of hazardous work conditions of chemical production on health state of the aged workers. When compared with the group aged under 45 years, prevalence of nervous, cardiovascular and locomotor diseases is 1.5-4 times higher in workers aged over 45 and engaged into main occupations (device operators, operators, fitters) in production of organic glass, dichloroethane, polyurethane foam and subjected continuously to chemicals 2 and more times exceeding MAC.

Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge.

Three new indole alkaloids, shearinines D, E, and F (1-3), together with the known shearinine A (4) were isolated from the marine-derived strain of the fungus Penicillium janthinellum Biourge. The chemical structures of 1-4 were established by 2D NMR and HREIMS data. Shearinines A, D, and E induce apoptosis in human leukemia HL-60 cells, and shearinine E also inhibits EGF-induced malignant transformation of JB6 P+ Cl 41 cells in a soft agar.

Bromoalterochromides A and A', unprecedented chromopeptides from a marine Pseudoalteromonas maricaloris strain KMM 636T.

The marine strain Pseudoalteromonas maricaloris KMM 636T was found to produce an inseparable mixture of two brominated yellow main pigments, bromoalterochromide A and A', in a ratio of 3: 1. Both pigments are Thr-Val-Asn-Asn-X pentapeptide lactones, where the amino group of Thr is acylated with 9-(3-bromo-4-hydroxyphenyl)-nona-2,4,6,8-tetraenoic acid, and X is aIle and Leu, respectively. They possess cytotoxic effects on developing eggs of the sea urchin Strongylocentrotus intermedius, but no antibiotic activity.

Controlling production of brominated cyclic depsipeptides by Pseudoalteromonas maricaloris KMM 636T.

Aims: This study aims at evaluating the impact of the nutrient medium components on the in vitro production of the cytotoxic alterochromides.

Methods And Results: The employment matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) facilitated the identification of a range of brominated cyclic depsipeptides with molecular masses of 843/845, 857/859 and 922/924/926 Da, and 936/938/940 Da produced by the marine bacterium Pseudoalteromonas maricaloris KMM 636T. The fractions of cytotoxic yellow pigments yielded after methanol extraction of P.