Publications by authors named "Smaranda R Badea"
Article Synopsis
- Chondroitin sulfate proteoglycans (CSPGs) hinder axonal growth and neuroplasticity following spinal cord injury.
- CSPGs block the conversion of pro-inflammatory immune cells to a pro-repair state, affecting recovery.
- Their action involves TLR4 signaling, which promotes prolonged inflammation and tissue damage post-injury.
Article Synopsis
- The COVID-19 pandemic continues until enough herd immunity is achieved through natural infections or vaccinations.
- Researchers designed two vaccine candidates focused on the immunodominant sites of the SARS-CoV-2 spike protein: one targeting just the Receptor Binding Domain (RBD) and another targeting all major sites.
- The study showed that the vaccine targeting all sites (S-ID) was more effective, leading to better antibody responses and reduced symptoms in vaccinated hamsters compared to the RBD-specific vaccine.
The clearance of damaged myelin sheaths is critical to ensure functional recovery from neural injury. Here we show a previously unidentified role for microvessels and their lining endothelial cells in engulfing myelin debris in spinal cord injury (SCI) and experimental autoimmune encephalomyelitis (EAE). We demonstrate that IgG opsonization of myelin debris is required for its effective engulfment by endothelial cells and that the autophagy-lysosome pathway is crucial for degradation of engulfed myelin debris.
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