Early mortality and temperature regulation in burned mice following administration of catecholamines and adrenergic receptor blocking drugs.

The effect of catecholamines and adrenergic receptor blocking drugs on mortality and body temperature was studied in mice subjected to burn, tourniquet, and endotoxin shock at an environmental temperature of 25 degrees C. Epinephrine and norepinephrine (0.5 mg/kg) injected intraperitoneally postburn increased shock mortality significantly (p less than 0.

Effect of thermal trauma on numbers and function of T and B cells from mouse spleen.

Swiss-Webster female mice were given a moderately severe burn, and studies were carried out on the number and function of T and B cells from the spleens of burned and normal mice. The results showed a significant decrease (p less than 0.05) in the number of T and B cells for 2-3 days after burning with a rapid return to normal and a subsequent rise above normal at 14 and 21 days postburn (p less than 0.

The role of histamine in burn, tourniquet and endotoxin shock in mice.

The release of histamine and mortality was studied in mice after various types of experimental shock. In burn shock, serum histamine rose significantly after injury, but there was no correlation between increased serum histamine and high mortality as a consequence of several therapy regimens. For example, after treatment with histamine or Compound 48/80 before burning, there was a rise of serum histamine, yet shock mortality fell significantly.

Protection against burn, tourniquet and endotoxin shock by histamine, 5-hydroxytryptamine and 5-hydroxytryptamine derivatives.

1. 5-Hydroxytryptamine (5-HT), tryptamine, 5-methyltryptamine, 5-methoxytryptamine, N-methyltryptamine, 5-hydroxy-N,N-dimethyltryptamine, and histamine markedly protect mice subjected to burn, tourniquet and endotoxin shock. All of these compounds protect when given 30 min before the production of shock, but not when administered afterwards.

Protection by vaccination against Pseudomonas infection after thermal injury.

Active immunization is effective in the prophylaxis of Pseudomonas septicemia in burned mice. Vaccines were prepared from bacterial cells and growth medium of Verder's 10 different O serological types of Pseudomonas aeruginosa strains, as well as from Escherichia coli and Proteus mirabilis. Mice given a tail burn could be significantly protected against a local Pseudomonas challenge by both specific and, to a lesser extent, by nonspecific Pseudomonas vaccines prepared either from bacterial cells or from the medium in which they were grown.