Improving the hemocompatibility of centrifugal mechanical circulatory support devices at low flow rates.

Background: An innovative solution has been recently proposed for the treatment of heart failure with preserved ejection fraction (HFpEF), using a centrifugal mechanical circulatory support (MCS) device. We sought firstly to assess the hemocompatibility of the proposed device. HFpEF treatment requires the blood pump to operate at low blood flow rate (0.

Numerical Assessment of the Hydrodynamic Behavior of a Volute Centrifugal Pump Handling Emulsion.

Although emulsion pumping is a subject of growing interest, a detailed analysis of the fluid dynamic phenomena occurring inside these machines is still lacking. Several computational investigations have been conducted to study centrifugal pumps carrying emulsion by analyzing their overall performance, but no studies involved the rheological behavior of such fluids. The purpose of this study is to perform a computational analysis of the performance and flow characteristics of a centrifugal pump with volute handling emulsions and oil-water mixtures at different water cuts modeled as a shear-thinning non-Newtonian fluid.

Improved Aerodynamics of a Hollow-Blade Axial Flow Fan by Controlling the Leakage Flow Rate by Air Injection at the Rotating Shroud.

Axial flow fans are used in many fields in order to ensure the mass and heat transfer from air, chiefly in the heating, ventilation and air conditioning industry (HVAC). A more proper understanding of the airflow behavior through the systems is necessary to manage and optimize the fan operation. Computational fluid dynamics (CFD) represents a real tool providing the ability to access flow structures in areas that measuring equipment cannot reach.

The evolution of long-term pediatric ventricular assistance devices: a critical review.

: The gap between the number of heart failure patients and the number of potential heart donors has never been larger than today, especially among the pediatric population. The use of mechanical circulatory support is seen as a potential alternative for clinicians to treat more patients. This treatment has proven its efficiency on short-term use.

Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films.

In this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects of drug concentration and Reynolds number defining the circulating flow in the testing vein. The experimental data used relate to the release of diclofenac from samples of non-degradable polyurethane subjected to static and continuous flow.

Numerical study of hemodynamic and diagnostic parameters affected by stenosis in bifurcated artery.

Stenosis in the bifurcated coronary artery has attracted wide attention among the researchers. Many investigations have been carried out by means of Computational Fluid Dynamics (CFD) to better understand the physical mechanism inside the stenotic bifurcated artery. However, the main focus of the existing publications is limited to the variation of hemodynamic parameters affected by the stenosis and bifurcation structure.