Search for 5'-leader regulatory RNA structures based on gene annotation aided by the RiboGap database.

The discovery of noncoding RNAs (ncRNAs) and their importance for gene regulation led us to develop bioinformatics tools to pursue the discovery of novel ncRNAs. Finding ncRNAs de novo is challenging, first due to the difficulty of retrieving large numbers of sequences for given gene activities, and second due to exponential demands on calculation needed for comparative genomics on a large scale. Recently, several tools for the prediction of conserved RNA secondary structure were developed, but many of them are not designed to uncover new ncRNAs, or are too slow for conducting analyses on a large scale.

Treatment of shigellosis with cefixime: two days vs. five days.

Background: Although the recommended standard course of therapy for shigellosis is 5 days of oral ampicillin or trimethoprim-sulfamethoxazole therapy, successful outcome has been reported in adults treated with abbreviated courses of antibiotics. The purpose of this study was to compare short course (2-day) vs. 5-day therapy with cefixime for treatment of diarrheal disease caused by Shigella sonnei in children.

Identification of the variables relevant to the recovery from post-surgical carpal tunnel syndrome.

The purpose of this paper is to determine what variables have been found to predict successful outcome for patients who have undergone carpal tunnel release surgery. In this case, 'successful' is defined as long-term relief of symptoms, pain free functional performance, or return to work. The variables have been divided into three major groups.