Increasing the versatility of the biphenyl-fused-dioxacyclodecyne class of strained alkynes.

Biphenyl-fused-dioxacyclodecynes are a promising class of strained alkyne for use in Cu-free 'click' reactions. In this paper, a series of functionalised derivatives of this class of reagent, containing fluorescent groups, are described. Studies aimed at understanding and increasing the reactivity of the alkynes are also presented, together with an investigation of the bioconjugation of the reagents with an azide-labelled protein.

Prevalence and route of transmission of undiagnosed human immunodeficiency virus infection among children using provider-initiated testing and counselling strategy in Ido-Ekiti, Nigeria: a cross-sectional study.

Introduction: Ninety-one percent of global Human Immunodeficiency Virus (HIV) infection in children occurs in sub-Saharan Africa. Provider Initiated Testing and Counselling (PITC) Strategy is a means of reducing missed opportunities for HIV exposed or infected children. The present study determined the prevalence of HIV infection using PITC Strategy among children seen at the Paediatric Emergency Unit of Federal Medical Centre (FMC), Ido-Ekiti, and the possible route of transmission.

Clinical predictors of aminoglycoside-induced ototoxicity in drug-resistant Tuberculosis patients on intensive therapy.

Objective: The study objectives were to determine the incidence of aminoglycoside-induced ototoxicity in institutionalized patients on intensive phase of therapy for drug-resistant Tuberculosis (DR Tb) and also to assess clinical factors which could predict the ototoxicity.

Methods: The study was a prospective analytical study among consecutive DR Tb patients who were admitted for intensive phase of therapy (of 4 months) at the DR-Tb center over a 12-month period. Patients were diagnosed as DR Tb using the Gene Xpert machine to confirm Rifampicin resistance.

Bacteriology of middle meatal aspirate of adult patients with chronic rhinosinusitis in Lagos. University Teaching Hospital, Lagos.

Background: Chronic rhinosinusitis (CRS) significantly lowers the quality of life of patients. The common use of broad spectrum antibiotics for its treatment may alter the pathogens that promote the persistence of this condition. However, the data concerning the distribution of bacteria species.

Pattern of skin sensitivity to various aeroallergens in bronchial asthmatic patients in Lagos, Nigeria.

Unlabelled: Background: Skin prick testing is an established way of investigating respiratory allergic diseases to determine the allergen or allergens responsible for clinical symptoms as well as degree of reactivity in the individual cases.

Objective: To study the skin sensitivity to various aeroallergens by skin prick test in selected asthmatic patients (with and without concurrent Allergic Rhinitis).

Design: A prospective case-control study.

KNOWLEDGE OF CERUMEN AND EFFECT OF EAR SELF-CLEANING AMONG HEALTH WORKERS IN A TERTIARY HOSPITAL.

Background: Ear wax lubricates, cleans and protects the external auditory canal while ear self-cleaning can lead to ear infections, trauma and perforation of the tympanic membrane. An erroneous understanding of these facts can lead to wrong practices with grievous consequences.

Objective: To assess the knowledge on ear wax and the effects of ear self-cleaning among health workers in Nigeria.

Allergic rhinitis among adult bronchial asthmatic patients in lagos, Nigeria.

Background: Allergic rhinitis (AR) and asthma are different manifestations of allergic disease of the airway. Both can exist together or as separate disease entity in an individual. However, it is not known if the coexistence of the two diseases can make asthmatic control difficult or not in the black population.

Rhinocerebral mucormycosis in a diabetic case report.

A 40 year old female Nigerian with uncontrolled diabetes mellitus was referred to a teaching hospital with four week history of facial rash that progressed to extensive ulceration of the mid face and bilateral visual loss. She had complete nasal bridge collapse, nasopalatal fistula with black eschars on the mucosa and markedly elevated fasting blood sugar. Her blood glucose was controlled on insulin, She had surgical debridement and histopathological study done revealed fungi hyphae.