[Treating treatment resistant catatonia with amantadine].

Catatonia is one of the most severe psychiatric syndromes, and clinical symptoms and etiology are very heterogeneous. When accompanied by autonomic instability and hyperthermia it’s termed malignant catatonia, which left untreated is associated with significant morbidity and mortality. First-line treatment is high dose benzodiazepines, followed by electroconvulsive therapy (ECT), in case of non-response.

[Data streams and limits to the use of patient data originating in (forensic) mental health care institutions].

Background: Patient data are not being used soley in the mental health care institutions in which the patients are being treated. Discussion about the legitimacy of using patient data for various purposes is hindered by a lack of clarity about the nature and content of the data streams.

Aim: To provide insight into the discrepancy between the purposes of collecting patient data and the purposes for which patient data are being used.

Towards an understanding of the mode of action of Bacillus Calmette-Guérin-therapy in bladder cancer treatment, especially with regard to the role of fibronectin.

The interaction between Bacillus Calmette-Guérin (BCG) and the host was investigated after repeated intravesicular BCG-therapy for superficial bladder cancer. Studies were performed on (a) the local reaction in the bladder, (b) the systemic reaction, and (c) short and long term interactions in both the bladder and the serum/plasma. The analytes measured included anti-BCG IgA and IgG, fibronectin, lactoferrin, elastase-alpha 1-proteinase inhibitor, myeloperoxidase and alpha 2-proteinase inhibitor.

The establishment and evaluation of luminescent-labelled immunometric assays for prostate-specific antigen-alpha 1-antichymotrypsin complexes in serum.

Prostate-specific antigen is found in the prostate in two forms, one with a low (30,000) and one with a high (100,000) relative molecular mass. The latter has recently been found to be a complex of prostate-specific antigen with alpha 1-antichymotrypsin. Immunoluminometric assays were designed for the prostate-specific antigen-alpha 1-antichymotrypsin complex as well as for alpha 1-antichymotrypsin, the former being compared with a commercially available radioimmunoassay for prostate-specific antigen (ProsChek RIA-Yang Laboratories).