Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion.

Treatment with the complex preparation containing pantogam, succinic acid, and chitosan normalized the concentration of reduced glutathione and activities of glutathione peroxidase, glutathione reductase, and some NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADPH-isocitrate dehydrogenase) in animals with experimental hypoxia/reperfusion of the brain. These results can be explained by suppression of free radical oxidation and normalization of the antioxidant system related to the neuroprotective, antihypoxic, and antioxidant properties of these substances, their involvement into the regulation of cell metabolism under pathological conditions accompanied by oxidative stress.

[Effect of succinic acid derivatives and chitosan on the oxidation status of tissues in rats with cerebral ischemia/reperfusion model].

The administration of chitosan succinate and N-succinylchitosan to rats with cerebral ischemia/reperfusion model damage leads to a decrease in the level of lactate (marker of ischemic injury development), parameters of biochemiluminescence (measure of free-radical oxidation intensity), and lipid peroxodation products in animal tissues as compared to untreated (pathologic) control. The obtained results show evidence of the ability of tested drugs to decrease the degree of oxidative stress manifestation under cerebral ischemia/reperfusion conditions, which is related to the positive control effect of chitosan-based drugs on the free-radical homeostasis.

Polymeric complexes of isonicotinic acid hydrazide with antituberculosis effects.

We studied the effects of an analogue of isonicotinic acid hydrazide on the treatment course of experimental tuberculosis. Complex analysis has demonstrated the efficiency of isonicotinic acid hydrazide immobilized on a carrier that consisted of water-soluble cation-active analogue of chitosan (N-chlorohydroxypropyl chitosan) in a complex with cobalt ions in the therapy of experimental tuberculosis. Immunostimulating activity of the polymeric metal complex was revealed.

[About improvement of outpatient dental health service for young serviceman].

The article gives a detailed account of results of epidemiological survey of dental morbidity in young serviceman and different types of outpatient dental health service needs. Medical norms for dispensary supply with all types of outpatient dental health service for young servicemen are estimated. Suggestions for improvement of organizational and staff structure of dental office of medical company are formulated.

Effect of N-[Imino(4-morpholyl)methyl]guanidine on the oxidative status in rats with toxic hepatitis.

The hepatoprotective and antioxidant properties of a synthetic biguanide N-[imino(4-morpholyl)methyl]guanidine (IMMG) were prognosticated by the method of computer prediction. Administration of IMMG was accompanied by a decrease in serum transaminase activity in rats with toxic hepatitis, which reflects inhibition of hepatocyte cytolysis. IMMG treatment was followed by a decrease in biochemiluminescence parameters reflecting the intensity of free radical oxidation.

[The influense of guanidine derivatives on free radical oxidation intensity and aconitase activity at development of brain ischemia-reperfusion at rats].

The study of some guanidine derivatives influence on free radical oxidation intensity and aconitase activity during the development of brain ischemia-reperfusion at rats has been carried out. The biochemiluminescence parameters increasing at the brain pathology changed toward normal values under the influence of N-[4-(chlorbenzoyl)benztiazol-2-yl]guanidine, N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine. The aconitase specific activity decreased in brain and blood of animals with ischemia-reperfusion.